Galectins in Inflammatory Skin Diseases: Mechanisms and Therapeutic Potential

Kayla Danesh; Feng Jen Lin; Hung Lin Chen; Fu Tong Liu

doi:10.1016/j.jid.2025.07.020

Galectins in Inflammatory Skin Diseases: Mechanisms and Therapeutic Potential

Kayla Danesh, Feng Jen Lin, Hung Lin Chen, Fu Tong Liu

Research output: Contribution to journal › Review article › peer-review

Abstract

This review examines the roles of galectins, a family of animal lectins, in inflammatory skin diseases, focusing on their involvement in the pathogenesis of psoriasis, atopic dermatitis, contact dermatitis, and common autoimmune diseases. We highlight the differential expression of galectins in lesional skin and their correlation with inflammatory mediators. In addition, we summarize the functions and mechanisms of action of endogenous galectins, as revealed through studies of genetically engineered cell lines and experimental animals. By synthesizing current research, this review underscores the opportunities for further studies to clarify the regulatory mechanisms of galectins in skin inflammation, aiming to enhance therapeutic strategies.

Original language	English
Journal	Journal of Investigative Dermatology
DOIs	https://doi.org/10.1016/j.jid.2025.07.020
Publication status	Published - 2025

Keywords

Atopic dermatitis
Autoimmune skin disease
Biomarkers
Immune response
Psoriasis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1016/j.jid.2025.07.020

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title = "Galectins in Inflammatory Skin Diseases: Mechanisms and Therapeutic Potential",

abstract = "This review examines the roles of galectins, a family of animal lectins, in inflammatory skin diseases, focusing on their involvement in the pathogenesis of psoriasis, atopic dermatitis, contact dermatitis, and common autoimmune diseases. We highlight the differential expression of galectins in lesional skin and their correlation with inflammatory mediators. In addition, we summarize the functions and mechanisms of action of endogenous galectins, as revealed through studies of genetically engineered cell lines and experimental animals. By synthesizing current research, this review underscores the opportunities for further studies to clarify the regulatory mechanisms of galectins in skin inflammation, aiming to enhance therapeutic strategies.",

keywords = "Atopic dermatitis, Autoimmune skin disease, Biomarkers, Immune response, Psoriasis",

author = "Kayla Danesh and Lin, \{Feng Jen\} and Chen, \{Hung Lin\} and Liu, \{Fu Tong\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

doi = "10.1016/j.jid.2025.07.020",

language = "English",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

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TY - JOUR

T1 - Galectins in Inflammatory Skin Diseases

T2 - Mechanisms and Therapeutic Potential

AU - Danesh, Kayla

AU - Lin, Feng Jen

AU - Chen, Hung Lin

AU - Liu, Fu Tong

PY - 2025

Y1 - 2025

N2 - This review examines the roles of galectins, a family of animal lectins, in inflammatory skin diseases, focusing on their involvement in the pathogenesis of psoriasis, atopic dermatitis, contact dermatitis, and common autoimmune diseases. We highlight the differential expression of galectins in lesional skin and their correlation with inflammatory mediators. In addition, we summarize the functions and mechanisms of action of endogenous galectins, as revealed through studies of genetically engineered cell lines and experimental animals. By synthesizing current research, this review underscores the opportunities for further studies to clarify the regulatory mechanisms of galectins in skin inflammation, aiming to enhance therapeutic strategies.

AB - This review examines the roles of galectins, a family of animal lectins, in inflammatory skin diseases, focusing on their involvement in the pathogenesis of psoriasis, atopic dermatitis, contact dermatitis, and common autoimmune diseases. We highlight the differential expression of galectins in lesional skin and their correlation with inflammatory mediators. In addition, we summarize the functions and mechanisms of action of endogenous galectins, as revealed through studies of genetically engineered cell lines and experimental animals. By synthesizing current research, this review underscores the opportunities for further studies to clarify the regulatory mechanisms of galectins in skin inflammation, aiming to enhance therapeutic strategies.

KW - Atopic dermatitis

KW - Autoimmune skin disease

KW - Biomarkers

KW - Immune response

KW - Psoriasis

UR - https://www.scopus.com/pages/publications/105015653768

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U2 - 10.1016/j.jid.2025.07.020

DO - 10.1016/j.jid.2025.07.020

M3 - Review article

C2 - 40920142

AN - SCOPUS:105015653768

SN - 0022-202X

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

ER -

Galectins in Inflammatory Skin Diseases: Mechanisms and Therapeutic Potential

Abstract

Keywords

ASJC Scopus subject areas

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