Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

Yu Shen Lin; Yann Hung; Jen Kuan Su; Rain Lee; Chen Chang; Meng Liang Lin; Chung Yuan Mou

doi:10.1021/jp047829a

Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

Yu Shen Lin
, Yann Hung
, Jen Kuan Su
, Rain Lee
, Chen Chang
, Meng Liang Lin
, Chung Yuan Mou

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, ²⁹Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r₁ and r₂, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

Original language	English
Pages (from-to)	15608-15611
Number of pages	4
Journal	Journal of Physical Chemistry B
Volume	108
Issue number	40
DOIs	https://doi.org/10.1021/jp047829a
Publication status	Published - Oct 7 2004
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Surfaces, Coatings and Films
Materials Chemistry

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10.1021/jp047829a

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title = "Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents",

abstract = "A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.",

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AU - Lin, Yu Shen

AU - Hung, Yann

AU - Su, Jen Kuan

AU - Lee, Rain

AU - Chang, Chen

AU - Lin, Meng Liang

AU - Mou, Chung Yuan

PY - 2004/10/7

Y1 - 2004/10/7

N2 - A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

AB - A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

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JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

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Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

Abstract

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