Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

Yu Shen Lin; Yann Hung; Jen Kuan Su; Rain Lee; Chen Chang; Meng Liang Lin; Chung Yuan Mou

doi:10.1021/jp047829a

Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

Yu Shen Lin, Yann Hung, Jen Kuan Su, Rain Lee, Chen Chang, Meng Liang Lin, Chung Yuan Mou

Research output: Contribution to journal › Article › peer-review

132 Citations (Scopus)

Abstract

A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, ²⁹Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r₁ and r₂, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

Original language	English
Pages (from-to)	15608-15611
Number of pages	4
Journal	Journal of Physical Chemistry B
Volume	108
Issue number	40
DOIs	https://doi.org/10.1021/jp047829a
Publication status	Published - Oct 7 2004
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Surfaces, Coatings and Films
Materials Chemistry

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abstract = "A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.",

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AU - Lin, Yu Shen

AU - Hung, Yann

AU - Su, Jen Kuan

AU - Lee, Rain

AU - Chang, Chen

AU - Lin, Meng Liang

AU - Mou, Chung Yuan

PY - 2004/10/7

Y1 - 2004/10/7

N2 - A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

AB - A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

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Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

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