G-Protein Coupled Estrogen Receptor in Breast Cancer

Li Han Hsu; Nei Min Chu; Yung Feng Lin; Shu Huei Kao

doi:10.3390/ijms20020306

G-Protein Coupled Estrogen Receptor in Breast Cancer

Li Han Hsu, Nei Min Chu, Yung Feng Lin, Shu Huei Kao

Research output: Contribution to journal › Review article › peer-review

66 Citations (Scopus)

Abstract

The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15% to 20% of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.

Original language	English
Article number	306
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	2
DOIs	https://doi.org/10.3390/ijms20020306
Publication status	Published - Jan 14 2019

Keywords

breast cancer
epidermal growth factor receptor
estrogen
estrogen receptor
G-protein coupled estrogen receptor

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms20020306

Cite this

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title = "G-Protein Coupled Estrogen Receptor in Breast Cancer",

abstract = "The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15% to 20% of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.",

keywords = "breast cancer, epidermal growth factor receptor, estrogen, estrogen receptor, G-protein coupled estrogen receptor",

author = "Hsu, {Li Han} and Chu, {Nei Min} and Lin, {Yung Feng} and Kao, {Shu Huei}",

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doi = "10.3390/ijms20020306",

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T1 - G-Protein Coupled Estrogen Receptor in Breast Cancer

AU - Hsu, Li Han

AU - Chu, Nei Min

AU - Lin, Yung Feng

AU - Kao, Shu Huei

PY - 2019/1/14

Y1 - 2019/1/14

N2 - The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15% to 20% of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.

AB - The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15% to 20% of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.

KW - breast cancer

KW - epidermal growth factor receptor

KW - estrogen

KW - estrogen receptor

KW - G-protein coupled estrogen receptor

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DO - 10.3390/ijms20020306

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ER -

G-Protein Coupled Estrogen Receptor in Breast Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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