Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Shih Hsiang Liao, Chia Hung Liu, Bishnu Prasad Bastakoti, Norihiro Suzuki, Yung Chang, Yusuke Yamauchi, Feng Huei Lin, Kevin C.W. Wu

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)


Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fuid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic feld, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.

Original languageEnglish
Pages (from-to)3315-3328
Number of pages14
JournalInternational Journal of Nanomedicine
Publication statusPublished - May 4 2015


  • Alginate
  • Hyperthermia
  • Iron oxide
  • Pre-gel
  • Targeting

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Drug Discovery
  • Organic Chemistry


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