10 Citations (Scopus)

Abstract

MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the let-7 family has been identified as a tumor suppressor in different types of cancers. However, the function of the let-7 family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of let-7g in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of let-7g. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of let-7g on CRC. We found that the expression of let-7g was significantly lower in CRC specimens. Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for let-7g in the pathogenesis of CRC and suggest let-7g as a potential therapeutic target for CRC treatment.

Original languageEnglish
Article number489
JournalCancers
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 1 2019

Keywords

  • Colorectal cancer
  • Let-7g
  • MicroRNA
  • Store-operated calcium (SOC)
  • The cancer genome atlas (TCGA)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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