TY - JOUR
T1 - Functional correlates of resting-state connectivity in the default mode network of heroin users on methadone treatment and medication-free therapeutic community program
AU - Kuo, Li Wei
AU - Lin, Pei Sheng
AU - Lin, Shih Yen
AU - Liu, Ming Fang
AU - Jan, Hengtai
AU - Lee, Hsin Chien
AU - Wang, Sheng Chang
N1 - Publisher Copyright:
Copyright © 2019 Kuo, Lin, Lin, Liu, Jan, Lee and Wang.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The treatment of heroin addiction is a complex process involving changes in addictive behavior and brain functioning. The goal of this study was to explore the brain default mode network (DMN) functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI) and decision-making performance based on the Cambridge gambling task in heroin-dependent individuals undergoing methadone treatment (MT, n = 11) and medication-free faith-based therapeutic community program (TC, n = 11). The DMN involved the medial prefrontal cortex (mPFC), left inferior parietal lobe (IPLL), right inferior parietal lobe (IPLR), and posterior cingulate cortex (PCC) subregions for all participants inboth the MT and TC groups. Compared with MT, TC had an increased functional connectivity in IPLL-IPLR and IPLR-PCC and decreased functional connectivity in mPFC-IPLL and IPLL-PCC. Both groups exhibited no significant difference in the regional rs-fMRI metric [i.e., amplitude of low-frequency fluctuation (ALFF)]. In the analysis of the neural correlates for decision-making performance, risk adjustment was positively associated with ALFF in IPLL for all participants considering the group effects. The involvement of IPL in decision-making performance and treatment response among heroin-dependent patients warrants further investigation.
AB - The treatment of heroin addiction is a complex process involving changes in addictive behavior and brain functioning. The goal of this study was to explore the brain default mode network (DMN) functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI) and decision-making performance based on the Cambridge gambling task in heroin-dependent individuals undergoing methadone treatment (MT, n = 11) and medication-free faith-based therapeutic community program (TC, n = 11). The DMN involved the medial prefrontal cortex (mPFC), left inferior parietal lobe (IPLL), right inferior parietal lobe (IPLR), and posterior cingulate cortex (PCC) subregions for all participants inboth the MT and TC groups. Compared with MT, TC had an increased functional connectivity in IPLL-IPLR and IPLR-PCC and decreased functional connectivity in mPFC-IPLL and IPLL-PCC. Both groups exhibited no significant difference in the regional rs-fMRI metric [i.e., amplitude of low-frequency fluctuation (ALFF)]. In the analysis of the neural correlates for decision-making performance, risk adjustment was positively associated with ALFF in IPLL for all participants considering the group effects. The involvement of IPL in decision-making performance and treatment response among heroin-dependent patients warrants further investigation.
KW - Cambridge Gambling Task
KW - Default Mode Network
KW - Heroin
KW - Methadone
KW - Resting-State Functional Magnetic Resonance Imaging
KW - Therapeutic Community
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U2 - 10.3389/fpsyt.2019.00381
DO - 10.3389/fpsyt.2019.00381
M3 - Article
AN - SCOPUS:85069542691
SN - 1664-0640
VL - 10
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
IS - JUN
M1 - 381
ER -
