@inproceedings{64e9236836b84541a27acc31408a28af,
title = "Fluorimetric determination of L-3-hydroxybutyrate concentrations in the serum of normal and aristolochic acid-treated mice",
abstract = "We determined the concentrations of L-3-hydroxybutyrate (L-3HB) in the serum of normal and aristolochic acid (AA)-treated mice. The samples were derivatized with 4-nitro-7-piperazino-2,1,3-benzoxadiazole (NBD-PZ) and determined fluorimetrically by column-switching high-performance liquid chromatography (HPLC). Total 3-HB derivatives in serum were separated by an ODS column and then introduced to a sample loop for enantiomeric separation by two tandem CHIRALCEL OD-RH columns. The results showed that the concentration of L-3HB in the serum of normal mice was 0.81 ± 0.15 μM compared to that of AA-treated mice with 4.33 ± 2.81 μM after 3 days and 8.65 ± 2.60 μM after 5 days of AA administration (p",
keywords = "L-3-hydroxybutyrate, column-switching HPLC, fluorimetric determination, renal damage",
author = "Chien-Ming Chen and Uen, {Yih Huei} and Kuo, {Chen Yi} and Huang, {Tzu Chuan} and Lee, {Jen Ai}",
year = "2009",
doi = "10.1007/978-3-642-10616-3_9",
language = "English",
isbn = "3642106153",
series = "Communications in Computer and Information Science",
pages = "63--68",
booktitle = "Bio-Science and Bio-Technology - International Conference, BSBT 2009. Held as Part of the Future Generation Information Technology Conference, FGIT 2009, Proceedings",
note = "International Conference on Bio-Science and Bio-Technology, BSBT 2009. Held as Part of the Future Generation Information Technology Conference, FGIT 2009 ; Conference date: 10-12-2009 Through 12-12-2009",
}