First description of Klebsiella pneumoniae harboring CTX-M β-lactamases (CTX-M-14 and CTX-M-3) in Taiwan

Liang Yu Wen; Patricia L. Winokur; Diana L. Von Stein; Michael A. Pfaller; Hsien Wang Jen; Ronald N. Jones

doi:10.1128/AAC.46.4.1098-1100.2002

First description of Klebsiella pneumoniae harboring CTX-M β-lactamases (CTX-M-14 and CTX-M-3) in Taiwan

Liang Yu Wen, Patricia L. Winokur, Diana L. Von Stein, Michael A. Pfaller, Hsien Wang Jen, Ronald N. Jones

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Klebsiella pneumoniae isolates from Taiwan medical centers (50 strains; 1998 to 2000) with a CTX-M resistance phenotype (ceftazidime susceptible and ceftriaxone or cefotaxime nonsusceptible) were selected for initial isoelectric focusing analysis. β-Lactamases with pIs of 7.9 (n = 22) and 8.4 (n = 28) in addition to 5.4 and/or 7.6 were detected. DNA gene sequencing identified the β-lactamases with pIs of 7.9 and 8.4 as CTX-M-14 and CTX-M-3, respectively. Molecular typing suggested inter- and intrahospital clonal dissemination of these Taiwanese CTX-M-producing Klebsiella strains.

Original language	English
Pages (from-to)	1098-1100
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	46
Issue number	4
DOIs	https://doi.org/10.1128/AAC.46.4.1098-1100.2002
Publication status	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.46.4.1098-1100.2002

Cite this

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title = "First description of Klebsiella pneumoniae harboring CTX-M β-lactamases (CTX-M-14 and CTX-M-3) in Taiwan",

abstract = "Klebsiella pneumoniae isolates from Taiwan medical centers (50 strains; 1998 to 2000) with a CTX-M resistance phenotype (ceftazidime susceptible and ceftriaxone or cefotaxime nonsusceptible) were selected for initial isoelectric focusing analysis. β-Lactamases with pIs of 7.9 (n = 22) and 8.4 (n = 28) in addition to 5.4 and/or 7.6 were detected. DNA gene sequencing identified the β-lactamases with pIs of 7.9 and 8.4 as CTX-M-14 and CTX-M-3, respectively. Molecular typing suggested inter- and intrahospital clonal dissemination of these Taiwanese CTX-M-producing Klebsiella strains.",

author = "Wen, {Liang Yu} and Winokur, {Patricia L.} and {Von Stein}, {Diana L.} and Pfaller, {Michael A.} and Jen, {Hsien Wang} and Jones, {Ronald N.}",

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AU - Wen, Liang Yu

AU - Winokur, Patricia L.

AU - Von Stein, Diana L.

AU - Pfaller, Michael A.

AU - Jen, Hsien Wang

AU - Jones, Ronald N.

PY - 2002

Y1 - 2002

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AB - Klebsiella pneumoniae isolates from Taiwan medical centers (50 strains; 1998 to 2000) with a CTX-M resistance phenotype (ceftazidime susceptible and ceftriaxone or cefotaxime nonsusceptible) were selected for initial isoelectric focusing analysis. β-Lactamases with pIs of 7.9 (n = 22) and 8.4 (n = 28) in addition to 5.4 and/or 7.6 were detected. DNA gene sequencing identified the β-lactamases with pIs of 7.9 and 8.4 as CTX-M-14 and CTX-M-3, respectively. Molecular typing suggested inter- and intrahospital clonal dissemination of these Taiwanese CTX-M-producing Klebsiella strains.

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First description of Klebsiella pneumoniae harboring CTX-M β-lactamases (CTX-M-14 and CTX-M-3) in Taiwan

Abstract

ASJC Scopus subject areas

UN SDGs

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