Fibroblast growth factor type 1 ameliorates high‐glucose‐induced oxidative stress and neuroinflammation in retinal pigment epithelial cells and a streptozotocin‐induced diabetic rat model

Hsin Wei Huang, Chung May Yang, Chang Hao Yang

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Diabetic retinopathy (DR) is a common complication of diabetes that causes severe visual impairment globally. The pathogenesis of DR is related to oxidative stress and chronic inflammation. The fibroblast growth factor type 1 (FGF‐1) mitogen plays crucial roles in cell function, development, and metabolism. FGF‐1 is involved in blood sugar regulation and exerts beneficial antioxidative and anti‐inflammatory effects on various organ systems. This study investigated the antiox-idative and anti‐inflammatory neuroprotective effects of FGF‐1 on high‐glucose‐induced retinal damage. The results revealed that FGF‐1 treatment significantly reversed the harmful effects of oxidative stress and inflammatory mediators in retinal tissue in a streptozotocin‐induced diabetic rat model. These protective effects were also observed in the in vitro model of retinal ARPE‐19 cells exposed to a high‐glucose condition. We demonstrated that FGF‐1 attenuated p38 mitogen‐activated protein kinase and nuclear factor‐κB pathway activation under the high‐glucose condition. Our results indicated that FGF‐1 could effectively prevent retinal injury in diabetes. The findings of this study could be used to develop novel treatments for DR that aim to reduce the cascade of oxidative stress and inflammatory signals in neuroretinal tissue.

Original languageEnglish
Article number7233
JournalInternational journal of molecular sciences
Volume22
Issue number13
DOIs
Publication statusPublished - Jul 2021

Keywords

  • Diabetic retinopathy
  • Fibroblast growth factor type 1
  • Inflammatory me-diator
  • Nuclear factor‐κB
  • Oxidative stress
  • P38 mitogen‐activated kinase

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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