TY - JOUR
T1 - Fever, Tachypnea, and Monocyte Distribution Width Predicts Length of Stay for Patients with COVID-19
T2 - A Pioneer Study
AU - Lin, Sheng Feng
AU - Lin, Hui An
AU - Chuang, Han Chuan
AU - Tsai, Hung Wei
AU - Kuo, Ning
AU - Chen, Shao Chun
AU - Hou, Sen Kuang
N1 - Funding Information:
This work was supported by the Taipei Medical University Hospital, Taipei, Taiwan. (Grant number: 108TMU-TMUH-13 and 109TMUH-NE-05).
Funding Information:
Funding: This work was supported by the Taipei Medical University Hospital, Taipei, Taiwan. (Grant number: 108TMU-TMUH-13 and 109TMUH-NE-05).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3
Y1 - 2022/3
N2 - (1) Background: Our study investigated whether monocyte distribution width (MDW) could be used in emergency department (ED) settings as a predictor of prolonged length of stay (LOS) for patients with COVID-19. (2) Methods: A retrospective cohort study was conducted; patients presenting to the ED of an academic hospital with confirmed COVID-19 were enrolled. Multivariable logistic regression models were used to obtain the odds ratios (ORs) for predictors of an LOS of >14 days. A validation study for the association between MDW and cycle of threshold (Ct) value was performed. (3) Results: Fever >38◦ C (OR: 2.82, 95% CI, 1.13–7.02, p = 0.0259), tachypnea (OR: 4.76, 95% CI, 1.67–13.55, p = 0.0034), and MDW ≥ 21 (OR: 5.67, 95% CI, 1.19–27.10, p = 0.0269) were robust significant predictors of an LOS of >14 days. We developed a new scoring system in which patients were assigned 1 point for fever > 38◦ C, 2 points for tachypnea > 20 breath/min, and 3 points for MDW ≥ 21. The optimal cutoff was a score of ≥2. MDW was negatively associated with Ct value (β: −0.32 per day, standard error = 0.12, p = 0.0099). (4) Conclusions: Elevated MDW was associated with a prolonged LOS.
AB - (1) Background: Our study investigated whether monocyte distribution width (MDW) could be used in emergency department (ED) settings as a predictor of prolonged length of stay (LOS) for patients with COVID-19. (2) Methods: A retrospective cohort study was conducted; patients presenting to the ED of an academic hospital with confirmed COVID-19 were enrolled. Multivariable logistic regression models were used to obtain the odds ratios (ORs) for predictors of an LOS of >14 days. A validation study for the association between MDW and cycle of threshold (Ct) value was performed. (3) Results: Fever >38◦ C (OR: 2.82, 95% CI, 1.13–7.02, p = 0.0259), tachypnea (OR: 4.76, 95% CI, 1.67–13.55, p = 0.0034), and MDW ≥ 21 (OR: 5.67, 95% CI, 1.19–27.10, p = 0.0269) were robust significant predictors of an LOS of >14 days. We developed a new scoring system in which patients were assigned 1 point for fever > 38◦ C, 2 points for tachypnea > 20 breath/min, and 3 points for MDW ≥ 21. The optimal cutoff was a score of ≥2. MDW was negatively associated with Ct value (β: −0.32 per day, standard error = 0.12, p = 0.0099). (4) Conclusions: Elevated MDW was associated with a prolonged LOS.
KW - Coronavirus 2019 (COVID-19)
KW - Fever
KW - Length of stay (LOS)
KW - Monocyte distribution width (MDW)
KW - Tachypnea
UR - http://www.scopus.com/inward/record.url?scp=85126935515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126935515&partnerID=8YFLogxK
U2 - 10.3390/jpm12030449
DO - 10.3390/jpm12030449
M3 - Article
AN - SCOPUS:85126935515
SN - 2075-4426
VL - 12
JO - Journal of Personalized Medicine
JF - Journal of Personalized Medicine
IS - 3
M1 - 449
ER -