Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

S. U. Chen; H. N. Ho; H. F. Chen; T. C. Tsai; T. Y. Lee; Y. S. Yang

doi:10.1016/s0015-0282(16)58406-4

Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

S. U. Chen
, H. N. Ho
, H. F. Chen
, T. C. Tsai
, T. Y. Lee
, Y. S. Yang

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Fertility and Sterility
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/s0015-0282(16)58406-4
Publication status	Published - Jan 1 1996
Externally published	Yes

Keywords

defective spermiogenesis
Intracytoplasmic spermatid injection
obstructive azoospermia

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology

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10.1016/s0015-0282(16)58406-4

Cite this

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title = "Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis",

abstract = "Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.",

keywords = "defective spermiogenesis, Intracytoplasmic spermatid injection, obstructive azoospermia",

author = "Chen, \{S. U.\} and Ho, \{H. N.\} and Chen, \{H. F.\} and Tsai, \{T. C.\} and Lee, \{T. Y.\} and Yang, \{Y. S.\}",

note = "Funding Information: Received September 12, 1995; revised and accepted February 5,1996. * Supported in part by grants from the National Science Council (NSC-82-412-B002-343), Taipei, Taiwan. t Department of Obstetrics and Gynecology. :\textbackslash{}: Reprint requests: Hong-Nerng Ho, M.D., Department of Obstetrics and Gynecology, National Taiwan University Hospital, No.7, Chung-Shan South Road, Taipei, Taiwan (FAX: 886-2-3418557). § Department of Urology.",

year = "1996",

month = jan,

day = "1",

doi = "10.1016/s0015-0282(16)58406-4",

language = "English",

volume = "66",

pages = "157--160",

journal = "Fertility and Sterility",

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TY - JOUR

T1 - Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

AU - Chen, S. U.

AU - Ho, H. N.

AU - Chen, H. F.

AU - Tsai, T. C.

AU - Lee, T. Y.

AU - Yang, Y. S.

N1 - Funding Information: Received September 12, 1995; revised and accepted February 5,1996. * Supported in part by grants from the National Science Council (NSC-82-412-B002-343), Taipei, Taiwan. t Department of Obstetrics and Gynecology. :\: Reprint requests: Hong-Nerng Ho, M.D., Department of Obstetrics and Gynecology, National Taiwan University Hospital, No.7, Chung-Shan South Road, Taipei, Taiwan (FAX: 886-2-3418557). § Department of Urology.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

AB - Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

KW - defective spermiogenesis

KW - Intracytoplasmic spermatid injection

KW - obstructive azoospermia

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DO - 10.1016/s0015-0282(16)58406-4

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C2 - 8752630

AN - SCOPUS:0029942297

SN - 0015-0282

VL - 66

SP - 157

EP - 160

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 1

ER -

Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

Abstract

Keywords

ASJC Scopus subject areas

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