Ferric Citrate Supplementation Reduces Red-Blood-Cell Aggregation and Improves CD163+ Macrophage-Mediated Hemoglobin Metabolism in a Rat Model of High-Fat-Diet-Induced Obesity

Agriculture & Biology

• high fat diet 64%
• obesity 62%
• citrates 57%
• macrophages 53%
• animal models 52%
• hemoglobin 51%
• erythrocytes 46%
• iron 43%
• metabolism 34%
• heme iron 24%
• heme oxygenase (biliverdin-producing) 24%
• rats 17%
• recycling 16%
• liver 15%
• diet 13%
• cathepsin D 11%
• protein degradation 9%
• dosage 8%
• cytochrome P-450 7%
• hepatocytes 7%
• staining 6%
• enzyme activity 5%
• methodology 4%
• cells 2%

Medicine & Life Sciences

• ferric citrate 100%
• Cell Aggregation 76%
• High Fat Diet 59%
• Iron 49%
• Hemoglobins 48%
• Erythrocytes 46%
• Macrophages 41%
• Obesity 41%
• Heme Oxygenase-1 15%
• Heme 14%
• Diet 13%
• LVV-hemorphin-7 13%
• Liver 10%
• NADPH-Ferrihemoprotein Reductase 9%
• Cathepsin D 8%
• Globins 8%
• Proteolysis 6%
• Sprague Dawley Rats 5%
• Hepatocytes 5%
• Pharmacology 4%
• Staining and Labeling 4%
• Enzymes 3%
• Serum 3%