TY - JOUR
T1 - Fatal Fulminant Cerebral Edema in Six Children With SARS-CoV-2 Omicron BA.2 Infection in Taiwan
AU - Lin, Jainn Jim
AU - Tu, Yi Fang
AU - Chen, Shyi Jou
AU - Kuo, Yung Ting
AU - Jeng, Mei Jy
AU - Hsin-Ju Ko, Mary
AU - Chiu, Cheng Hsun
N1 - Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2023/2/27
Y1 - 2023/2/27
N2 - Acute fulminant cerebral edema in children following SARS-CoV-2 infection has been rarely reported. Such patients frequently demonstrate rapid progression and are usually fatal. In this retrospective study, we describe the detailed clinical, laboratory, and neuroimaging features of six fatal cases in Taiwan. All patients had shock initially, five showed rapid progression to multiorgan failure and disseminated intravascular coagulation, and three developed acute respiratory distress syndromes. The inflammatory biomarkers in the first 3 days, including interleukin 6, ferritin, lactate dehydrogenase, and D-dimer, showed significant elevation in all cases. The hyperinflammatory response may play a role in the pathophysiology.
AB - Acute fulminant cerebral edema in children following SARS-CoV-2 infection has been rarely reported. Such patients frequently demonstrate rapid progression and are usually fatal. In this retrospective study, we describe the detailed clinical, laboratory, and neuroimaging features of six fatal cases in Taiwan. All patients had shock initially, five showed rapid progression to multiorgan failure and disseminated intravascular coagulation, and three developed acute respiratory distress syndromes. The inflammatory biomarkers in the first 3 days, including interleukin 6, ferritin, lactate dehydrogenase, and D-dimer, showed significant elevation in all cases. The hyperinflammatory response may play a role in the pathophysiology.
KW - COVID-19
KW - fulminant cerebral edema
KW - hypercytokinemia
KW - Omicron BA.2
KW - pediatric
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U2 - 10.1093/jpids/piac116
DO - 10.1093/jpids/piac116
M3 - Article
C2 - 36369959
AN - SCOPUS:85148965930
SN - 2048-7193
VL - 12
SP - 99
EP - 103
JO - Journal of the Pediatric Infectious Diseases Society
JF - Journal of the Pediatric Infectious Diseases Society
IS - 2
ER -
