TY - JOUR
T1 - Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies. II. Chromosomal and immunologic abnormalities
AU - Law, Ivan P.
AU - Hollinshead, Ariel C.
AU - Whang‐Peng, Jacqueline
AU - Dean, Jack H.
AU - Oldham, Robert K.
AU - Herberman, Ronald B.
AU - Rhode, Marvin C.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell‐mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.
AB - Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell‐mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.
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U2 - 10.1002/1097-0142(197703)39:3<1229::AID-CNCR2820390331>3.0.CO;2-J
DO - 10.1002/1097-0142(197703)39:3<1229::AID-CNCR2820390331>3.0.CO;2-J
M3 - Article
C2 - 303145
AN - SCOPUS:0017345745
SN - 0008-543X
VL - 39
SP - 1229
EP - 1236
JO - Cancer
JF - Cancer
IS - 3
ER -
