Familial Nonmedullary Thyroid Cancer: An Emerging Entity That Warrants Aggressive Treatment

Richard F. Grossman, Shih Hsin Tu, Quan Yang Duh, Allan E. Siperstein, Faina Novosolov, Orlo H. Clark

Research output: Contribution to journalArticlepeer-review

146 Citations (Scopus)


To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of follicular cell origin. Retrospective review. University medical center. Fourteen patients were treated for familial nonmedullary thyroid carcinoma between 1980 and 1994. Thirteen families were identified, with 30 affected individuals. Patients were treated with total or completion total thyroidectomy. Thirteen additional operations were performed to control recurrent disease. Stage, recurrence, and survival. Patients were followed up for a mean of 6.5 years. In our 14 patients, 13 tumors were multifocal, and six of these were bilateral. The incidences of lymph node metastasis and local invasion were both 57% (n=8). Seven patients (50%) had recurrences during follow-up. Familial nonmedullary thyroid carcinoma has a high incidence of multifocality and invasion and a high rate of local recurrence. Aggressive initial treatment and careful follow-up seem to be indicated.

Original languageEnglish
Pages (from-to)892-899
Number of pages8
JournalArchives of Surgery
Issue number8
Publication statusPublished - Aug 1995

ASJC Scopus subject areas

  • Surgery


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