Factors affecting survival of medulloblastoma in children: the changing concept of management

Tai Tong Wong; Yen Lin Liu; Donald Ming Tak Ho; Kai Ping Chang; Muh Lii Liang; Hsin Hung Chen; Yi Yen Lee; Feng Chi Chang; Shih Chieh Lin; Ting Rong Hsu; Kuo Wei Chen; Wei Kang Kwang; Wu Yu Hou; Chung Yih Wang; Sang Hue Yen; Wan You Guo; Yi Wei Chen

doi:10.1007/s00381-015-2884-2

Factors affecting survival of medulloblastoma in children: the changing concept of management

Tai Tong Wong, Yen Lin Liu, Donald Ming Tak Ho, Kai Ping Chang, Muh Lii Liang, Hsin Hung Chen, Yi Yen Lee, Feng Chi Chang, Shih Chieh Lin, Ting Rong Hsu, Kuo Wei Chen, Wei Kang Kwang, Wu Yu Hou, Chung Yih Wang, Sang Hue Yen, Wan You Guo, Yi Wei Chen

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16 Citations (Scopus)

Abstract

Medulloblastoma (MB) is a type of malignant tumor arising only in the cerebellum that was first defined by Cushing and Bailey in 1920s. In this review paper, we trace the evolution of risk stratification and the correlated changing concept of management in the past years. Outcome analysis of the hospital series of the Taipei Veterans General Hospital, Cheng Hsin General Hospital, and Taipei Medical University Hospital was performed to correlate prognostic indicators with reported studies. The purpose is to provide clues for age-specific and risk-adjusted optimal, effective, but beneficial and protective treatment strategies of these tumors in children.

Original language	English
Pages (from-to)	1687-1698
Number of pages	12
Journal	Child's Nervous System
Volume	31
Issue number	10
DOIs	https://doi.org/10.1007/s00381-015-2884-2
Publication status	Published - Oct 13 2015

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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Wong, T. T., Liu, Y. L., Ho, D. M. T., Chang, K. P., Liang, M. L., Chen, H. H., Lee, Y. Y., Chang, F. C., Lin, S. C., Hsu, T. R., Chen, K. W., Kwang, W. K., Hou, W. Y., Wang, C. Y., Yen, S. H., Guo, W. Y., & Chen, Y. W. (2015). Factors affecting survival of medulloblastoma in children: the changing concept of management. Child's Nervous System, 31(10), 1687-1698. https://doi.org/10.1007/s00381-015-2884-2

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abstract = "Medulloblastoma (MB) is a type of malignant tumor arising only in the cerebellum that was first defined by Cushing and Bailey in 1920s. In this review paper, we trace the evolution of risk stratification and the correlated changing concept of management in the past years. Outcome analysis of the hospital series of the Taipei Veterans General Hospital, Cheng Hsin General Hospital, and Taipei Medical University Hospital was performed to correlate prognostic indicators with reported studies. The purpose is to provide clues for age-specific and risk-adjusted optimal, effective, but beneficial and protective treatment strategies of these tumors in children.",

author = "Wong, {Tai Tong} and Liu, {Yen Lin} and Ho, {Donald Ming Tak} and Chang, {Kai Ping} and Liang, {Muh Lii} and Chen, {Hsin Hung} and Lee, {Yi Yen} and Chang, {Feng Chi} and Lin, {Shih Chieh} and Hsu, {Ting Rong} and Chen, {Kuo Wei} and Kwang, {Wei Kang} and Hou, {Wu Yu} and Wang, {Chung Yih} and Yen, {Sang Hue} and Guo, {Wan You} and Chen, {Yi Wei}",

note = "Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (grant number NSC102-2314-B-038-060-MY3); Health and Welfare Surcharge of Tobacco Products, Taiwan (grant number MOHW104-TDU-B-212-124-001); and Taipei Medical University Hospital, Taipei, Taiwan (grant number 104TMU-TMUH-11). Publisher Copyright: {\textcopyright} 2015, Springer-Verlag Berlin Heidelberg.",

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doi = "10.1007/s00381-015-2884-2",

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T2 - the changing concept of management

AU - Wong, Tai Tong

AU - Liu, Yen Lin

AU - Ho, Donald Ming Tak

AU - Chang, Kai Ping

AU - Liang, Muh Lii

AU - Chen, Hsin Hung

AU - Lee, Yi Yen

AU - Chang, Feng Chi

AU - Lin, Shih Chieh

AU - Hsu, Ting Rong

AU - Chen, Kuo Wei

AU - Kwang, Wei Kang

AU - Hou, Wu Yu

AU - Wang, Chung Yih

AU - Yen, Sang Hue

AU - Guo, Wan You

AU - Chen, Yi Wei

N1 - Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (grant number NSC102-2314-B-038-060-MY3); Health and Welfare Surcharge of Tobacco Products, Taiwan (grant number MOHW104-TDU-B-212-124-001); and Taipei Medical University Hospital, Taipei, Taiwan (grant number 104TMU-TMUH-11). Publisher Copyright: © 2015, Springer-Verlag Berlin Heidelberg.

PY - 2015/10/13

Y1 - 2015/10/13

N2 - Medulloblastoma (MB) is a type of malignant tumor arising only in the cerebellum that was first defined by Cushing and Bailey in 1920s. In this review paper, we trace the evolution of risk stratification and the correlated changing concept of management in the past years. Outcome analysis of the hospital series of the Taipei Veterans General Hospital, Cheng Hsin General Hospital, and Taipei Medical University Hospital was performed to correlate prognostic indicators with reported studies. The purpose is to provide clues for age-specific and risk-adjusted optimal, effective, but beneficial and protective treatment strategies of these tumors in children.

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Factors affecting survival of medulloblastoma in children: the changing concept of management

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