Fabrication of electrospun (ES) hydrophilic PLA95/biocerimic membranes for GTR/GBR applications

Hsin Tai Hu; Hong Da Wu; Chang Chia-Hsiang; Sheng Yang Lee; Jen Chang Yang

Fabrication of electrospun (ES) hydrophilic PLA95/biocerimic membranes for GTR/GBR applications

Hsin Tai Hu, Hong Da Wu, Chang Chia-Hsiang, Sheng Yang Lee, Jen Chang Yang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The concept of guided tissue/bone regeneration (GTR/GBR) is using a barrier to maintain a space in order to prevent the migration of faster-growing soft tissue into the defect for ligament (PDL), cementum and bone reconstruction in dentistry. The aim of this study is to fabricate fibrous PLA95 (poly-5D/95L-lactide) /bioceramic membranes via electrospinning (ES) technique. Bio-ceramic such as calcium sulfate /phosphate (α-CaSO₄/β- TCP) were chosen as fillers for co- electrospinning because of their osteoconductivity. The surface properties of hybrid ES membranes were modified to improve the hydrophobic properties by a dip-coating method. The physical and mechanical properties of ES membranes were explored. The morphology, structure, wettability, and suture strength of ES membranes were evaluated by SEM, XRD, contact angle and tensile tester, respectively. The resulted PLA95/bio-ceramic membranes show nice hydrophilic and good mechanical properties. The results of cytotoxicity test confirm those ES membranes would not induce any cell toxicity. Base on these results, we have successfully prepared composites of osteoconductive, hydrophilic and porous 3-D GTR/GBR membranes. The membrane system can be used as a prototype for the further development in many other clinical uses.

Original language	English
Title of host publication	7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
Publisher	ACCM-7 Organizing Committee
Pages	958-961
Number of pages	4
Volume	2
ISBN (Print)	9781632660756
Publication status	Published - 2010
Event	7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 - Taipei, Taiwan Duration: Nov 15 2010 → Nov 18 2010

Other

Other	7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
Country/Territory	Taiwan
City	Taipei
Period	11/15/10 → 11/18/10

Keywords

Calcium sulfate/phosphate
Electrospinning
Guided tissue/bone regeneration (GTR/GBR)
Mechanical properties
Wettability

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials

Cite this

Hu, HT, Wu, HD, Chia-Hsiang, C, Lee, SY & Yang, JC 2010, Fabrication of electrospun (ES) hydrophilic PLA95/biocerimic membranes for GTR/GBR applications. in 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. vol. 2, ACCM-7 Organizing Committee, pp. 958-961, 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010, Taipei, Taiwan, 11/15/10.

@inproceedings{04d1ec888c6a42a8a805d3be56fa1a43,

title = "Fabrication of electrospun (ES) hydrophilic PLA95/biocerimic membranes for GTR/GBR applications",

abstract = "The concept of guided tissue/bone regeneration (GTR/GBR) is using a barrier to maintain a space in order to prevent the migration of faster-growing soft tissue into the defect for ligament (PDL), cementum and bone reconstruction in dentistry. The aim of this study is to fabricate fibrous PLA95 (poly-5D/95L-lactide) /bioceramic membranes via electrospinning (ES) technique. Bio-ceramic such as calcium sulfate /phosphate (α-CaSO4/β- TCP) were chosen as fillers for co- electrospinning because of their osteoconductivity. The surface properties of hybrid ES membranes were modified to improve the hydrophobic properties by a dip-coating method. The physical and mechanical properties of ES membranes were explored. The morphology, structure, wettability, and suture strength of ES membranes were evaluated by SEM, XRD, contact angle and tensile tester, respectively. The resulted PLA95/bio-ceramic membranes show nice hydrophilic and good mechanical properties. The results of cytotoxicity test confirm those ES membranes would not induce any cell toxicity. Base on these results, we have successfully prepared composites of osteoconductive, hydrophilic and porous 3-D GTR/GBR membranes. The membrane system can be used as a prototype for the further development in many other clinical uses.",

keywords = "Calcium sulfate/phosphate, Electrospinning, Guided tissue/bone regeneration (GTR/GBR), Mechanical properties, Wettability",

author = "Hu, {Hsin Tai} and Wu, {Hong Da} and Chang Chia-Hsiang and Lee, {Sheng Yang} and Yang, {Jen Chang}",

year = "2010",

language = "English",

isbn = "9781632660756",

volume = "2",

pages = "958--961",

booktitle = "7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010",

publisher = "ACCM-7 Organizing Committee",

note = "7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 ; Conference date: 15-11-2010 Through 18-11-2010",

}

TY - GEN

T1 - Fabrication of electrospun (ES) hydrophilic PLA95/biocerimic membranes for GTR/GBR applications

AU - Hu, Hsin Tai

AU - Wu, Hong Da

AU - Chia-Hsiang, Chang

AU - Lee, Sheng Yang

AU - Yang, Jen Chang

PY - 2010

Y1 - 2010

N2 - The concept of guided tissue/bone regeneration (GTR/GBR) is using a barrier to maintain a space in order to prevent the migration of faster-growing soft tissue into the defect for ligament (PDL), cementum and bone reconstruction in dentistry. The aim of this study is to fabricate fibrous PLA95 (poly-5D/95L-lactide) /bioceramic membranes via electrospinning (ES) technique. Bio-ceramic such as calcium sulfate /phosphate (α-CaSO4/β- TCP) were chosen as fillers for co- electrospinning because of their osteoconductivity. The surface properties of hybrid ES membranes were modified to improve the hydrophobic properties by a dip-coating method. The physical and mechanical properties of ES membranes were explored. The morphology, structure, wettability, and suture strength of ES membranes were evaluated by SEM, XRD, contact angle and tensile tester, respectively. The resulted PLA95/bio-ceramic membranes show nice hydrophilic and good mechanical properties. The results of cytotoxicity test confirm those ES membranes would not induce any cell toxicity. Base on these results, we have successfully prepared composites of osteoconductive, hydrophilic and porous 3-D GTR/GBR membranes. The membrane system can be used as a prototype for the further development in many other clinical uses.

AB - The concept of guided tissue/bone regeneration (GTR/GBR) is using a barrier to maintain a space in order to prevent the migration of faster-growing soft tissue into the defect for ligament (PDL), cementum and bone reconstruction in dentistry. The aim of this study is to fabricate fibrous PLA95 (poly-5D/95L-lactide) /bioceramic membranes via electrospinning (ES) technique. Bio-ceramic such as calcium sulfate /phosphate (α-CaSO4/β- TCP) were chosen as fillers for co- electrospinning because of their osteoconductivity. The surface properties of hybrid ES membranes were modified to improve the hydrophobic properties by a dip-coating method. The physical and mechanical properties of ES membranes were explored. The morphology, structure, wettability, and suture strength of ES membranes were evaluated by SEM, XRD, contact angle and tensile tester, respectively. The resulted PLA95/bio-ceramic membranes show nice hydrophilic and good mechanical properties. The results of cytotoxicity test confirm those ES membranes would not induce any cell toxicity. Base on these results, we have successfully prepared composites of osteoconductive, hydrophilic and porous 3-D GTR/GBR membranes. The membrane system can be used as a prototype for the further development in many other clinical uses.

KW - Calcium sulfate/phosphate

KW - Electrospinning

KW - Guided tissue/bone regeneration (GTR/GBR)

KW - Mechanical properties

KW - Wettability

UR - http://www.scopus.com/inward/record.url?scp=84905504440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905504440&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84905504440

SN - 9781632660756

VL - 2

SP - 958

EP - 961

BT - 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010

PB - ACCM-7 Organizing Committee

T2 - 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010

Y2 - 15 November 2010 through 18 November 2010

ER -

Fabrication of electrospun (ES) hydrophilic PLA95/biocerimic membranes for GTR/GBR applications

Abstract

Other

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this