TY - GEN
T1 - Fabrication of electrospun (ES) hydrophilic PLA95/biocerimic membranes for GTR/GBR applications
AU - Hu, Hsin Tai
AU - Wu, Hong Da
AU - Chia-Hsiang, Chang
AU - Lee, Sheng Yang
AU - Yang, Jen Chang
PY - 2010
Y1 - 2010
N2 - The concept of guided tissue/bone regeneration (GTR/GBR) is using a barrier to maintain a space in order to prevent the migration of faster-growing soft tissue into the defect for ligament (PDL), cementum and bone reconstruction in dentistry. The aim of this study is to fabricate fibrous PLA95 (poly-5D/95L-lactide) /bioceramic membranes via electrospinning (ES) technique. Bio-ceramic such as calcium sulfate /phosphate (α-CaSO4/β- TCP) were chosen as fillers for co- electrospinning because of their osteoconductivity. The surface properties of hybrid ES membranes were modified to improve the hydrophobic properties by a dip-coating method. The physical and mechanical properties of ES membranes were explored. The morphology, structure, wettability, and suture strength of ES membranes were evaluated by SEM, XRD, contact angle and tensile tester, respectively. The resulted PLA95/bio-ceramic membranes show nice hydrophilic and good mechanical properties. The results of cytotoxicity test confirm those ES membranes would not induce any cell toxicity. Base on these results, we have successfully prepared composites of osteoconductive, hydrophilic and porous 3-D GTR/GBR membranes. The membrane system can be used as a prototype for the further development in many other clinical uses.
AB - The concept of guided tissue/bone regeneration (GTR/GBR) is using a barrier to maintain a space in order to prevent the migration of faster-growing soft tissue into the defect for ligament (PDL), cementum and bone reconstruction in dentistry. The aim of this study is to fabricate fibrous PLA95 (poly-5D/95L-lactide) /bioceramic membranes via electrospinning (ES) technique. Bio-ceramic such as calcium sulfate /phosphate (α-CaSO4/β- TCP) were chosen as fillers for co- electrospinning because of their osteoconductivity. The surface properties of hybrid ES membranes were modified to improve the hydrophobic properties by a dip-coating method. The physical and mechanical properties of ES membranes were explored. The morphology, structure, wettability, and suture strength of ES membranes were evaluated by SEM, XRD, contact angle and tensile tester, respectively. The resulted PLA95/bio-ceramic membranes show nice hydrophilic and good mechanical properties. The results of cytotoxicity test confirm those ES membranes would not induce any cell toxicity. Base on these results, we have successfully prepared composites of osteoconductive, hydrophilic and porous 3-D GTR/GBR membranes. The membrane system can be used as a prototype for the further development in many other clinical uses.
KW - Calcium sulfate/phosphate
KW - Electrospinning
KW - Guided tissue/bone regeneration (GTR/GBR)
KW - Mechanical properties
KW - Wettability
UR - http://www.scopus.com/inward/record.url?scp=84905504440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905504440&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84905504440
SN - 9781632660756
T3 - 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
SP - 958
EP - 961
BT - 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
PB - ACCM-7 Organizing Committee
T2 - 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
Y2 - 15 November 2010 through 18 November 2010
ER -