Fabrication of a promising hierarchical porous surface on titanium for promoting biocompatibility

Wen Chien Lan, Chia Hsien Wang, Bai Hung Huang, Yen Chun Cho, Takashi Saito, Chien Chia Huang, Mao Suan Huang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The effects of the nano-titanium hydrides (nano-γ-TiH) phase on the formation of nanoporous Ti oxide layer by the potential approach (hydrogen fluoride (HF) pretreatment and sodium hydroxide (NaOH) anodization) were investigated using scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, and transmission electron microscopy. The nano-γ-TiH phase was formed by the HF pretreatment with various current densities. After the NaOH anodization, the nano-γ-TiH phase was dissolved and transformed into nanoporous rutile-Ti dioxide (R-TiO2). As the Ti underwent HF pretreatment and NaOH anodization, the microstructure on the surface layer was transformed from α-Ti→(α-Ti + nano-γ-TiH)→(α-Ti + R-TiO2). In-vitro biocompatibility also indicated that the Ti with a hierarchical porous (micro and nanoporous) TiO2 surface possessed great potential to enhance cell adhesion ability. Thus, the potential approach can be utilized to fabricate a promising hierarchical porous surface on the Ti implant for promoting biocompatibility.

Original languageEnglish
Article number1363
JournalApplied Sciences (Switzerland)
Issue number4
Publication statusPublished - Feb 1 2020


  • Anodization
  • Biocompatibility
  • Titanium hydride
  • Titanium oxide

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes


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