EZH2 in cancer progression and potential application in cancer therapy: A friend or foe?

Ke Sin Yan; Chia Yuan Lin; Tan Wei Liao; Cheng Ming Peng; Shou Chun Lee; Yi Jui Liu; Wing P. Chan; Ruey Hwang Chou

doi:10.3390/ijms18061172

EZH2 in cancer progression and potential application in cancer therapy: A friend or foe?

Ke Sin Yan, Chia Yuan Lin, Tan Wei Liao, Cheng Ming Peng, Shou Chun Lee, Yi Jui Liu, Wing P. Chan, Ruey Hwang Chou

Research output: Contribution to journal › Review article › peer-review

76 Citations (Scopus)

Abstract

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes trimethylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms, depending on the different cellular contexts. EZH2 interacts with both histone and non-histone proteins to modulate diverse physiological functions including cancer progression and malignancy. In this review article, we focused on the updated information regarding microRNAs (miRNAs) and long non coding RNAs (lncRNAs) in regulation of EZH2, the oncogenic and tumor suppressive roles of EZH2 in cancer progression and malignancy, as well as current pre-clinical and clinical trials of EZH2 inhibitors.

Original language	English
Article number	1172
Journal	International journal of molecular sciences
Volume	18
Issue number	6
DOIs	https://doi.org/10.3390/ijms18061172
Publication status	Published - Jun 2017

Keywords

Cancer
EZH2
EZH2 inhibitors
Epigenetic regulation
lncRNAs
microRNAs

ASJC Scopus subject areas

Molecular Biology
Spectroscopy
Catalysis
Inorganic Chemistry
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms18061172

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title = "EZH2 in cancer progression and potential application in cancer therapy: A friend or foe?",

abstract = "Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes trimethylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms, depending on the different cellular contexts. EZH2 interacts with both histone and non-histone proteins to modulate diverse physiological functions including cancer progression and malignancy. In this review article, we focused on the updated information regarding microRNAs (miRNAs) and long non coding RNAs (lncRNAs) in regulation of EZH2, the oncogenic and tumor suppressive roles of EZH2 in cancer progression and malignancy, as well as current pre-clinical and clinical trials of EZH2 inhibitors.",

keywords = "Cancer, EZH2, EZH2 inhibitors, Epigenetic regulation, lncRNAs, microRNAs",

author = "Yan, {Ke Sin} and Lin, {Chia Yuan} and Liao, {Tan Wei} and Peng, {Cheng Ming} and Lee, {Shou Chun} and Liu, {Yi Jui} and Chan, {Wing P.} and Chou, {Ruey Hwang}",

note = "Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2017",

month = jun,

doi = "10.3390/ijms18061172",

language = "English",

volume = "18",

journal = "International journal of molecular sciences",

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T1 - EZH2 in cancer progression and potential application in cancer therapy

T2 - A friend or foe?

AU - Yan, Ke Sin

AU - Lin, Chia Yuan

AU - Liao, Tan Wei

AU - Peng, Cheng Ming

AU - Lee, Shou Chun

AU - Liu, Yi Jui

AU - Chan, Wing P.

AU - Chou, Ruey Hwang

PY - 2017/6

Y1 - 2017/6

N2 - Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes trimethylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms, depending on the different cellular contexts. EZH2 interacts with both histone and non-histone proteins to modulate diverse physiological functions including cancer progression and malignancy. In this review article, we focused on the updated information regarding microRNAs (miRNAs) and long non coding RNAs (lncRNAs) in regulation of EZH2, the oncogenic and tumor suppressive roles of EZH2 in cancer progression and malignancy, as well as current pre-clinical and clinical trials of EZH2 inhibitors.

AB - Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes trimethylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms, depending on the different cellular contexts. EZH2 interacts with both histone and non-histone proteins to modulate diverse physiological functions including cancer progression and malignancy. In this review article, we focused on the updated information regarding microRNAs (miRNAs) and long non coding RNAs (lncRNAs) in regulation of EZH2, the oncogenic and tumor suppressive roles of EZH2 in cancer progression and malignancy, as well as current pre-clinical and clinical trials of EZH2 inhibitors.

KW - Cancer

KW - EZH2

KW - EZH2 inhibitors

KW - Epigenetic regulation

KW - lncRNAs

KW - microRNAs

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DO - 10.3390/ijms18061172

M3 - Review article

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VL - 18

JO - International journal of molecular sciences

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ER -

EZH2 in cancer progression and potential application in cancer therapy: A friend or foe?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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