TY - JOUR
T1 - Eyes-Open and Eyes-Closed Resting State Network Connectivity Differences
AU - Han, Junrong
AU - Zhou, Liwei
AU - Wu, Hang
AU - Huang, Yujuan
AU - Qiu, Mincong
AU - Huang, Likai
AU - Lee, Chia
AU - Lane, Timothy Joseph
AU - Qin, Pengmin
N1 - Funding Information:
Data collection: research assistant, scanning schedules, scanning fees, operator fees and subject recruitment for the Taiwan data set were supported by grants to T.J.L. from Taiwan Ministries of Health and Welfare, Education and Science and Technology (105-2410-H-038-004-MY1, 106-2410-H-038-003-MY3, 109-2410-H-038-009, 111-2410-H-038-012, DP2-110-21121-01-N-07-01, DP2-111-21121-01-N-05-01, 110IIT-03 and 111TMU-SHH-22). This research was also funded by [Key Realm R&D Program of Guangzhou] under Grant [number 202007030005]; [the National Natural Science Foundation of China] under Grant [number 31971032]; [the Major Program of National Social Science Foundation of China] under Grant [number 18ZDA293]; [Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Fund] under Grant [number 2019023]; [Key-Area Research and Development Program of Guangdong Province] under Grant [number 2019B030335001]; [Guangdong Basic and Applied Basic Research Foundation] under Grant [number 2020A1515011250]; 2022 the Guangdong-Hong Kong-Macao Greater Bay Area Exchange Programs of SCNU.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/1
Y1 - 2023/1
N2 - Resting state networks comprise several brain regions that exhibit complex patterns of interaction. Switching from eyes closed (EC) to eyes open (EO) during the resting state modifies these patterns of connectivity, but precisely how these change remains unclear. Here we use functional magnetic resonance imaging to scan healthy participants in two resting conditions (viz., EC and EO). Seven resting state networks were chosen for this study: salience network (SN), default mode network (DMN), central executive network (CEN), dorsal attention network (DAN), visual network (VN), motor network (MN) and auditory network (AN). We performed functional connectivity (FC) analysis for each network, comparing the FC maps for both EC and EO. Our results show increased connectivity between most networks during EC relative to EO, thereby suggesting enhanced integration during EC and greater modularity or specialization during EO. Among these networks, SN is distinctive: during the transition from EO to EC it evinces increased connectivity with DMN and decreased connectivity with VN. This change might imply that SN functions in a manner analogous to a circuit switch, modulating resting state relations with DMN and VN, when transitioning between EO and EC.
AB - Resting state networks comprise several brain regions that exhibit complex patterns of interaction. Switching from eyes closed (EC) to eyes open (EO) during the resting state modifies these patterns of connectivity, but precisely how these change remains unclear. Here we use functional magnetic resonance imaging to scan healthy participants in two resting conditions (viz., EC and EO). Seven resting state networks were chosen for this study: salience network (SN), default mode network (DMN), central executive network (CEN), dorsal attention network (DAN), visual network (VN), motor network (MN) and auditory network (AN). We performed functional connectivity (FC) analysis for each network, comparing the FC maps for both EC and EO. Our results show increased connectivity between most networks during EC relative to EO, thereby suggesting enhanced integration during EC and greater modularity or specialization during EO. Among these networks, SN is distinctive: during the transition from EO to EC it evinces increased connectivity with DMN and decreased connectivity with VN. This change might imply that SN functions in a manner analogous to a circuit switch, modulating resting state relations with DMN and VN, when transitioning between EO and EC.
KW - eyes closed
KW - eyes open
KW - fMRI
KW - resting state network
KW - salience network
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U2 - 10.3390/brainsci13010122
DO - 10.3390/brainsci13010122
M3 - Article
AN - SCOPUS:85146753489
SN - 2076-3425
VL - 13
JO - Brain Sciences
JF - Brain Sciences
IS - 1
M1 - 122
ER -