Extremely long-term survival of chronic myelogenous leukemia in a male with absence of the Y chromosome.

W. S. Wang, T. J. Chiou, I. T. Yu, P. M. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

A male patient survived for 15 years after the diagnosis of chronic myelogenous leukemia (CML) without bone marrow transplantation (BMT). He had initially received busulfan for eight months with an excellent response, then had been without any treatment for 13 years. During that long period, the white blood cell count kept around 10,000/microL and the spleen was not enlarged. The cytogenetic study revealed Philadelphia chromosome (Ph) in the blood cells with the absence of Y chromosome. Some authors have suggested that the absence of Y chromosome in Ph (+) bone marrow cells of male CML patients is often associated with a benign course. Our patient with this kind of cytogenetic abnormality survived for 15 years. This is, to the best of our knowledge, the second longest record of survival among CML patients in English literature. Relevant literature about chromosomal abnormalities and their influence on prognosis of CML is reviewed.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalZhonghua yi xue za zhi = Chinese medical journal; Free China ed
Volume58
Issue number2
Publication statusPublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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