Extremely elevated CA19-9 in acute cholangitis

Shyr Ming Sheen-Chen, Cheuk Kwan Sun, Yei Wei Liu, Hock Liew Eng, Sheung Fat Ko, Chung Huang Kuo

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


A 68-year-old women was admitted with the chief complaints of epigastralgia with radiation to the back and jaundice. Fever and chills were also noted. The laboratory data showed alkaline phosphatase, 245 U/L (normal range: 28-94); Direct Bilirubin, 5.29 mg% (0-0.4); Total Bilirubin, 8.4 mg% (0.2-1.4). Surprisingly, the serum CA19-9 was 5673.8 U/ml (normal value: <37). Abdominal sonography showed dilated common hepatic duct. MRCP demonstrated diffuse biliary tree dilatation with a very low signal intensity in distal common bile duct. Surgical intervention reveled a black stone at distal common bile duct and was successfully retrieved. After operation, the CA19-9 fell to 63.1 u/ml two weeks later and returned to normal (10.4 U/ml) one month later.

Original languageEnglish
Pages (from-to)3140-3142
Number of pages3
JournalDigestive Diseases and Sciences
Issue number11
Publication statusPublished - Nov 1 2007
Externally publishedYes


  • Acute cholangitis
  • CA19-9

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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