Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Yu Hsuan Kuo, Ai Li Shiau, Chao Ling Tung, Yu Chu Su, Chien Feng Li, Bing Hua Su, Chao Jung Tsao, Chao Liang Wu, Yin Hsun Feng, Pensee Wu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Prothymosin α (ProTα) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProTα expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProTα-positive lung cancer. Immunohistochemical staining of ProTα was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProTα and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57%) were classified as ProTα-positive lung cancer by staining intensity and 73 tumors (49%) were regarded as ProTα-positive by scoring index. The majority of patients with ProTα-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProTα by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProTα expression. ProTα was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProTα-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes.

Original languageEnglish
Pages (from-to)5740-5746
Number of pages7
JournalOncology Letters
Issue number6
Publication statusPublished - Jun 2019


  • Cigarettes
  • Lung cancer
  • Prothymosin α
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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