Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma

Min Cheng Su; Chun Ting Chen; Fang I. Huang; Yu Ling Chen; Yung Ming Jeng; Chiao Ying Lin

doi:10.1016/j.jfma.2013.07.012

Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma

Min Cheng Su
, Chun Ting Chen
, Fang I. Huang
, Yu Ling Chen
, Yung Ming Jeng
, Chiao Ying Lin

School of Dentistry

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Background/Purpose: Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LEF1 in 135 cases of OSCC were determined by immunohistochemistry. The results were correlated with clinicopathologic parameters and patient outcome. Results: LEF1 was only occasionally detected in basal and parabasal cells of nontumorous squamous epithelium. Overexpression of LEF1 was observed in 33 of 135 OSCCs (24%). LEF1 was more frequently expressed in moderately to poorly differentiated cancer (. p=0.0035) and was associated with lymphovascular invasion (. p=0.0252). Overexpression of LEF1 was significantly associated with poor prognosis (. p=0.0176, hazard ratio=1.96, 95% CI=1.02-3.75). Multivariate analysis revealed LEF1expression and margin status to be the significant independent predictors for overall survival. Conclusion: Our study suggests LEF1 expression in OSCC may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with OSCC.

Original language	English
Pages (from-to)	934-939
Number of pages	6
Journal	Journal of the Formosan Medical Association
Volume	113
Issue number	12
DOIs	https://doi.org/10.1016/j.jfma.2013.07.012
Publication status	Published - Dec 1 2014

Keywords

Immunohistochemistry
LEF1
Oral squamous cell carcinoma
Prognosis

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jfma.2013.07.012

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title = "Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma",

abstract = "Background/Purpose: Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LEF1 in 135 cases of OSCC were determined by immunohistochemistry. The results were correlated with clinicopathologic parameters and patient outcome. Results: LEF1 was only occasionally detected in basal and parabasal cells of nontumorous squamous epithelium. Overexpression of LEF1 was observed in 33 of 135 OSCCs (24\%). LEF1 was more frequently expressed in moderately to poorly differentiated cancer (. p=0.0035) and was associated with lymphovascular invasion (. p=0.0252). Overexpression of LEF1 was significantly associated with poor prognosis (. p=0.0176, hazard ratio=1.96, 95\% CI=1.02-3.75). Multivariate analysis revealed LEF1expression and margin status to be the significant independent predictors for overall survival. Conclusion: Our study suggests LEF1 expression in OSCC may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with OSCC.",

keywords = "Immunohistochemistry, LEF1, Oral squamous cell carcinoma, Prognosis",

author = "Su, \{Min Cheng\} and Chen, \{Chun Ting\} and Huang, \{Fang I.\} and Chen, \{Yu Ling\} and Jeng, \{Yung Ming\} and Lin, \{Chiao Ying\}",

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doi = "10.1016/j.jfma.2013.07.012",

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AU - Su, Min Cheng

AU - Chen, Chun Ting

AU - Huang, Fang I.

AU - Chen, Yu Ling

AU - Jeng, Yung Ming

AU - Lin, Chiao Ying

PY - 2014/12/1

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N2 - Background/Purpose: Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LEF1 in 135 cases of OSCC were determined by immunohistochemistry. The results were correlated with clinicopathologic parameters and patient outcome. Results: LEF1 was only occasionally detected in basal and parabasal cells of nontumorous squamous epithelium. Overexpression of LEF1 was observed in 33 of 135 OSCCs (24%). LEF1 was more frequently expressed in moderately to poorly differentiated cancer (. p=0.0035) and was associated with lymphovascular invasion (. p=0.0252). Overexpression of LEF1 was significantly associated with poor prognosis (. p=0.0176, hazard ratio=1.96, 95% CI=1.02-3.75). Multivariate analysis revealed LEF1expression and margin status to be the significant independent predictors for overall survival. Conclusion: Our study suggests LEF1 expression in OSCC may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with OSCC.

AB - Background/Purpose: Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LEF1 in 135 cases of OSCC were determined by immunohistochemistry. The results were correlated with clinicopathologic parameters and patient outcome. Results: LEF1 was only occasionally detected in basal and parabasal cells of nontumorous squamous epithelium. Overexpression of LEF1 was observed in 33 of 135 OSCCs (24%). LEF1 was more frequently expressed in moderately to poorly differentiated cancer (. p=0.0035) and was associated with lymphovascular invasion (. p=0.0252). Overexpression of LEF1 was significantly associated with poor prognosis (. p=0.0176, hazard ratio=1.96, 95% CI=1.02-3.75). Multivariate analysis revealed LEF1expression and margin status to be the significant independent predictors for overall survival. Conclusion: Our study suggests LEF1 expression in OSCC may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with OSCC.

KW - Immunohistochemistry

KW - LEF1

KW - Oral squamous cell carcinoma

KW - Prognosis

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Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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