Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review

Jie-Ru You; Ya-Ting Chen; Chia-Yu Hsieh; Sin-Yu Chen; Tzu-Yao Lin; Jing-Syuan Shih; Guan-Ting Chen; Sheng-Wei Feng; Tzu-Yu Peng; Chia-Yu Wu; I-Ta Lee

doi:10.3390/cancers15194812

Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review

Jie-Ru You, Ya-Ting Chen, Chia-Yu Hsieh, Sin-Yu Chen, Tzu-Yao Lin, Jing-Syuan Shih, Guan-Ting Chen, Sheng-Wei Feng, Tzu-Yu Peng, Chia-Yu Wu, I-Ta Lee

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Oral submucous fibrosis (OSF) stands as a progressive oral ailment, designated as a potentially malignant disorder. OSF has gained widespread recognition as a significant precursor to malignant transformation. In the pursuit of dependable, straightforward, and non-invasive diagnostic measures for the early detection of oral malignant progression, research has delved into potential diagnostic biomarkers of OSF. This comprehensive review delves into current investigations that explore the correlation between various biomarkers and OSF. The molecular biomarkers of OSF are categorized based on cytology and sampling methods. Moreover, this review encompasses pertinent studies detailing how these biomarkers are acquired and processed. Within this scope, we scrutinize four potential biomarkers that hold the promise of facilitating the development of diagnostic tools for detecting early-stage OSF.

Original language	English
Article number	4812
Journal	Cancers
Volume	15
Issue number	19
DOIs	https://doi.org/10.3390/cancers15194812
Publication status	Published - Sept 2023

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title = "Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review",

abstract = "Oral submucous fibrosis (OSF) stands as a progressive oral ailment, designated as a potentially malignant disorder. OSF has gained widespread recognition as a significant precursor to malignant transformation. In the pursuit of dependable, straightforward, and non-invasive diagnostic measures for the early detection of oral malignant progression, research has delved into potential diagnostic biomarkers of OSF. This comprehensive review delves into current investigations that explore the correlation between various biomarkers and OSF. The molecular biomarkers of OSF are categorized based on cytology and sampling methods. Moreover, this review encompasses pertinent studies detailing how these biomarkers are acquired and processed. Within this scope, we scrutinize four potential biomarkers that hold the promise of facilitating the development of diagnostic tools for detecting early-stage OSF.",

keywords = "oral submucous fibrosis, biomarker, precancer malignant transformation, oral epithelium, microvessel density",

author = "Jie-Ru You and Ya-Ting Chen and Chia-Yu Hsieh and Sin-Yu Chen and Tzu-Yao Lin and Jing-Syuan Shih and Guan-Ting Chen and Sheng-Wei Feng and Tzu-Yu Peng and Chia-Yu Wu and I-Ta Lee",

year = "2023",

month = sep,

doi = "10.3390/cancers15194812",

language = "English",

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journal = "Cancers",

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T1 - Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review

AU - You, Jie-Ru

AU - Chen, Ya-Ting

AU - Hsieh, Chia-Yu

AU - Chen, Sin-Yu

AU - Lin, Tzu-Yao

AU - Shih, Jing-Syuan

AU - Chen, Guan-Ting

AU - Feng, Sheng-Wei

AU - Peng, Tzu-Yu

AU - Wu, Chia-Yu

AU - Lee, I-Ta

PY - 2023/9

Y1 - 2023/9

N2 - Oral submucous fibrosis (OSF) stands as a progressive oral ailment, designated as a potentially malignant disorder. OSF has gained widespread recognition as a significant precursor to malignant transformation. In the pursuit of dependable, straightforward, and non-invasive diagnostic measures for the early detection of oral malignant progression, research has delved into potential diagnostic biomarkers of OSF. This comprehensive review delves into current investigations that explore the correlation between various biomarkers and OSF. The molecular biomarkers of OSF are categorized based on cytology and sampling methods. Moreover, this review encompasses pertinent studies detailing how these biomarkers are acquired and processed. Within this scope, we scrutinize four potential biomarkers that hold the promise of facilitating the development of diagnostic tools for detecting early-stage OSF.

AB - Oral submucous fibrosis (OSF) stands as a progressive oral ailment, designated as a potentially malignant disorder. OSF has gained widespread recognition as a significant precursor to malignant transformation. In the pursuit of dependable, straightforward, and non-invasive diagnostic measures for the early detection of oral malignant progression, research has delved into potential diagnostic biomarkers of OSF. This comprehensive review delves into current investigations that explore the correlation between various biomarkers and OSF. The molecular biomarkers of OSF are categorized based on cytology and sampling methods. Moreover, this review encompasses pertinent studies detailing how these biomarkers are acquired and processed. Within this scope, we scrutinize four potential biomarkers that hold the promise of facilitating the development of diagnostic tools for detecting early-stage OSF.

KW - oral submucous fibrosis

KW - biomarker

KW - precancer malignant transformation

KW - oral epithelium

KW - microvessel density

U2 - 10.3390/cancers15194812

DO - 10.3390/cancers15194812

M3 - Review article

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 19

M1 - 4812

ER -

Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review

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