TY - JOUR
T1 - Exploring anti-inflammatory non-essential oil metabolites in Mentha canadensis
T2 - Insights into neutrophil extracellular trap inhibition for functional health promotion
AU - Le, Huong Giang
AU - Chen, Yun Shiuan
AU - Cheng, Tzu Peng
AU - Tsai, Yung Fong
AU - Chen, Po Jen
AU - Cheng, Wen Chi
AU - El-Shazly, Mohamed
AU - Chang, Yu Chia
AU - Hwang, Tsong Long
AU - Lai, Kuei Hung
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/6
Y1 - 2024/6
N2 - Mentha canadensis, commonly known as Canadian mint, has been utilized in herbal medicine for its menthol content, addressing digestive and respiratory issues. It also serves as a popular culinary herb, adding a refreshing minty flavor to dishes and beverages. However, research on its non-essential oils and their anti-inflammatory potential is lacking. This study utilized multi-informative molecular networking to comprehensively profile the non-essential oils of M. canadensis. Cinnamic acid derivatives were identified as potent anti-inflammatory agents, with high activity ratings. By analyzing the Molecular Networking (MN) database, fourteen metabolites were identified. Compounds within the bioactive MN clusters demonstrate significant inhibition of reactive oxygen species generation, playing a crucial role in the management of oxidative stress. These compounds also effectively suppressed the formation of neutrophil extracellular traps. In conclusion, salvianolic acid B (IC50: 0.08 μM) was promoted as the chemical marker of M. canadensis for its potential anti-inflammatory effect. This study pioneers the identification of anti-inflammatory metabolites in M. canadensis' non-essential oils, offering insights into its therapeutic properties and potential for health-centric culinary applications.
AB - Mentha canadensis, commonly known as Canadian mint, has been utilized in herbal medicine for its menthol content, addressing digestive and respiratory issues. It also serves as a popular culinary herb, adding a refreshing minty flavor to dishes and beverages. However, research on its non-essential oils and their anti-inflammatory potential is lacking. This study utilized multi-informative molecular networking to comprehensively profile the non-essential oils of M. canadensis. Cinnamic acid derivatives were identified as potent anti-inflammatory agents, with high activity ratings. By analyzing the Molecular Networking (MN) database, fourteen metabolites were identified. Compounds within the bioactive MN clusters demonstrate significant inhibition of reactive oxygen species generation, playing a crucial role in the management of oxidative stress. These compounds also effectively suppressed the formation of neutrophil extracellular traps. In conclusion, salvianolic acid B (IC50: 0.08 μM) was promoted as the chemical marker of M. canadensis for its potential anti-inflammatory effect. This study pioneers the identification of anti-inflammatory metabolites in M. canadensis' non-essential oils, offering insights into its therapeutic properties and potential for health-centric culinary applications.
KW - Mentha canadensis L.
KW - multi-informative molecular networking
KW - NETs formation
KW - neutrophil
KW - ROS-dependent anti-inflammation
KW - Mentha canadensis L.
KW - multi-informative molecular networking
KW - NETs formation
KW - neutrophil
KW - ROS-dependent anti-inflammation
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U2 - 10.1016/j.jff.2024.106233
DO - 10.1016/j.jff.2024.106233
M3 - Article
AN - SCOPUS:85193068601
SN - 1756-4646
VL - 117
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 106233
ER -