Exploration of microbiota targets for major depressive disorder and mood related traits

Yu Chu Ella Chung, Hsi Chung Chen, Hsiang Chin Lori Chou, I. Ming Chen, Meei Shyuan Lee, Li Chung Chuang, Yen Wenn Liu, Mong Liang Lu, Chun Hsin Chen, Chi Hsin Wu, Ming Chyi Huang, Shih Cheng Liao, Yen Hsuan Ni, Mei Shu Lai, Wei Liang Shih, Po Hsiu Kuo

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


Growing evidence suggests the link between gut microbiota and mood regulation. The current study aimed to identify microbiota targets for major depressive disorder (MDD) and mood-related traits in Taiwanese samples, while taking into account the influence of dietary patterns. We recruited 36 MDD patients and 37 healthy controls for 16S rRNA gene sequencing. We assessed nutrient content using food frequency questionnaire, and mood related phenotypes, including depressive severity, anxiety, and perceived stress. Analysis of composition of microbiomes (ANCOM) models were performed to evaluate microbiota compositions between patients and controls, while adjusted for fat intake% and sequencing platforms. We found 23 taxa (4 phyla, 7 families and 12 genera) to be associated with depression and beta diversity was differed between groups. Phylum Actinobacteria and Firmicutes were overrepresented in MDD patients. At genus level, Bifidobacterium (7%) and Blautia (8%) had relatively high abundance among MDD patients, while Prevotella (16%) had high abundance in controls. Holdemania exhibited moderate correlation with anxiety (r = 0.65) and perceived stress level (r = 0.49) mainly in MDD patients but not controls. Pathway analyses revealed that pentose phosphate and starch and sucrose metabolism processes were important pathways for depression via microbiota functions. In conclusion, our results revealed microbiota targets for depression that are independent of fat intake. It is worthwhile to conduct further studies to replicate the current findings and to integrate with biochemistry and metabolomics data to better understand the functions of identified targets.

Original languageEnglish
Pages (from-to)74-82
Number of pages9
JournalJournal of Psychiatric Research
Publication statusPublished - Apr 1 2019


  • Anxiety
  • Gut-brain axis
  • Major depressive disorder
  • Microbiota
  • Perceived stress

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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