Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

Yi Fan Chen; Frank Luh; Yuan Soon Ho; Yun Yen

doi:10.1186/s12929-024-01055-0

Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

Yi Fan Chen, Frank Luh, Yuan Soon Ho, Yun Yen

Research output: Contribution to journal › Review article › peer-review

Abstract

Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.

Original language	English
Article number	67
Journal	Journal of Biomedical Science
Volume	31
Issue number	1
DOIs	https://doi.org/10.1186/s12929-024-01055-0
Publication status	Published - Dec 2024

Keywords

Cancer diagnosis
Cancer therapy
Exosome
siRNA

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Molecular Biology
Clinical Biochemistry
Cell Biology
Biochemistry, medical
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12929-024-01055-0

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title = "Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials",

abstract = "Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.",

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T2 - a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

AU - Chen, Yi Fan

AU - Luh, Frank

AU - Ho, Yuan Soon

AU - Yen, Yun

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/12

Y1 - 2024/12

N2 - Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.

AB - Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.

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KW - Cancer therapy

KW - Exosome

KW - siRNA

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ER -

Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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