Evolution of pulmonary valve reconstruction with focused review of expanded polytetrafluoroethylene handmade valves

Te I. Chang, Kang Hong Hsu, Shao Jung Li, Min Kai Chuang, Chi Wen Luo, Yi Jen Chen, Chung I. Chang

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


OBJECTIVES: Many surgeons develop unique techniques for unmet needs for right ventricular outflow reconstruction to resolve pulmonary regurgitation after corrective surgery for congenital heart diseases. Expanded polytetrafluoroethylene (ePTFE) stands out as a reliable synthetic material, and clinical results with handmade ePTFE valves have been promising. This review focuses on the historical evolution of the use of ePTFE in pulmonary valve replacement and in the techniques for pioneering the translation of the handmade ePTFE trileaflet design for the transcatheter approach. METHODS: We searched for and reviewed publications from 1990 to 2020 in the Pubmed database. Nineteen clinical studies from 2005 to 2019 that focused on ePTFE-based valves were summarized. The evolution of the ePTFE-based valve over 3 decades and recent relevant in vitro studies were investigated. RESULTS: The average freedom from reintervention or surgery in the recorded ePTFE-based valve population was 90.2% at 5 years, and the survival rate was 96.7% at 3 years. CONCLUSIONS: Non-inferior clinical results of this ePTFE handmade valve were revealed compared to allograft or xenograft options for pulmonary valve replacement. Future investigations on transferring ePTFE trileaflet design to transcatheter devices should be considered.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalInteractive Cardiovascular and Thoracic Surgery
Issue number4
Publication statusPublished - Apr 19 2021


  • Expanded polytetrafluoroethylene valve
  • Handmade pulmonary valve
  • Pulmonary transcatheter device
  • Pulmonary valve replacement

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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