TY - JOUR
T1 - Evaluation of the antihyperuricemic activity of phytochemicals from Davallia formosana by enzyme assay and hyperuricemic mice model
AU - Chen, Chen Yu
AU - Huang, Chi Chang
AU - Tsai, Keng Chang
AU - Huang, Wei Jan
AU - Huang, Wen Ching
AU - Hsu, Yu Chen
AU - Hsu, Feng-Lin
PY - 2014
Y1 - 2014
N2 - Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect of Davallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C- β-d-glucopyranoside (1), 6,8,3′,4′-tetrahydroxyflavanone-7-C- β-d-glucopyranoside (2), 6,8,4′-trihydroxyflavanone-7-C-β-d- glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O-β-d- allopyranoside (4), and epiphyllocoumarin-3-O-β-d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds 3 and 5 significantly inhibited XOD activity in vitro and reduced serum uric acid levels in vivo. This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.
AB - Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect of Davallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C- β-d-glucopyranoside (1), 6,8,3′,4′-tetrahydroxyflavanone-7-C- β-d-glucopyranoside (2), 6,8,4′-trihydroxyflavanone-7-C-β-d- glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O-β-d- allopyranoside (4), and epiphyllocoumarin-3-O-β-d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds 3 and 5 significantly inhibited XOD activity in vitro and reduced serum uric acid levels in vivo. This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.
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U2 - 10.1155/2014/873607
DO - 10.1155/2014/873607
M3 - Article
AN - SCOPUS:84901812219
SN - 1741-427X
VL - 2014
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 873607
ER -