Evaluation of surface characteristics and hemocompatibility on the oxygen plasma-modified biomedical titanium

Hsi Jen Chiang, Hsin Hua Chou, Keng Liang Ou, Erwan Sugiatno, Muhammad Ruslin, Rahmat Abd Waris, Chiung Fang Huang, Chung Ming Liu, Pei Wen Peng

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Oxygen plasma with different treatment powers and durations was utilized to modify the biomedical pure titanium (Ti) surface in the present study. The superficial, microstructural and biological properties of the plasma-oxidized samples were investigated using the electron microscopy, X-ray photoemission spectroscopy, grazing incidence X-ray diffractometer, contact angle goniometer and blood clotting time assay. During different treatment powers and durations, the island-like nanostructural rutile-TiO2 layer and dimple-like nanostructural rutile-TiO2 layer were generated on the surfaces of the plasma-oxidized samples, respectively. It was also found that the plasma-oxidized sample with a rough oxide layer resulted in the formation of a higher wettability. Moreover, the blood clotting time assay indicated that the plasma-oxidized samples exhibited the adhesion behaviors of red blood cells. As the Ti surface underwent plasma oxidation at 280 W for 30 min, it not only generates a rough nanostructural rutile-TiO2 layer, but also presents an excellent hemocompatibility. Therefore, these findings demonstrate that oxygen plasma modification is a potential approach to promote the hemocompatibility of biomedical pure Ti surface.

Original languageEnglish
Article number513
Pages (from-to)513
Issue number7
Publication statusPublished - Jul 2018


  • Hemocompatibility
  • Oxygen plasma treatment
  • Titanium dioxide
  • Wettability

ASJC Scopus subject areas

  • Metals and Alloys
  • General Materials Science


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