Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test

Ming Fang Wu; Fu Chuo Peng; Yung Liang Chen; Ching Sung Lee; Yi Yuan Yang; Ming Yang Yeh; Chi Ming Liu; Jin Biou Chang; Rick Sai Chuen Wu; Chieh Chih Yu; Hsu Feng Lu; Jing Gung Chung

Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test

Ming Fang Wu, Fu Chuo Peng, Yung Liang Chen, Ching Sung Lee, Yi Yuan Yang, Ming Yang Yeh, Chi Ming Liu, Jin Biou Chang, Rick Sai Chuen Wu, Chieh Chih Yu, Hsu Feng Lu, Jing Gung Chung

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.

Original language	English
Pages (from-to)	419-423
Number of pages	5
Journal	In Vivo
Volume	25
Issue number	3
Publication status	Published - May 2011

Keywords

Ames test
Antrodia cinnamomea
Chromosomal aberration test
Genotoxicity

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test",

abstract = "Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.",

keywords = "Ames test, Antrodia cinnamomea, Chromosomal aberration test, Genotoxicity",

author = "Wu, {Ming Fang} and Peng, {Fu Chuo} and Chen, {Yung Liang} and Lee, {Ching Sung} and Yang, {Yi Yuan} and Yeh, {Ming Yang} and Liu, {Chi Ming} and Chang, {Jin Biou} and Wu, {Rick Sai Chuen} and Yu, {Chieh Chih} and Lu, {Hsu Feng} and Chung, {Jing Gung}",

year = "2011",

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language = "English",

volume = "25",

pages = "419--423",

journal = "In Vivo",

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AU - Wu, Ming Fang

AU - Peng, Fu Chuo

AU - Chen, Yung Liang

AU - Lee, Ching Sung

AU - Yang, Yi Yuan

AU - Yeh, Ming Yang

AU - Liu, Chi Ming

AU - Chang, Jin Biou

AU - Wu, Rick Sai Chuen

AU - Yu, Chieh Chih

AU - Lu, Hsu Feng

AU - Chung, Jing Gung

PY - 2011/5

Y1 - 2011/5

N2 - Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.

AB - Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.

KW - Ames test

KW - Antrodia cinnamomea

KW - Chromosomal aberration test

KW - Genotoxicity

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Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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