Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

K. T. Vu Thai; M. C. Yang; W. F. Lai

Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

K. T. Vu Thai, M. C. Yang, W. F. Lai

Taipei Medical University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (T_gel), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature due to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.

Original language	English
Title of host publication	Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages	187-190
Number of pages	4
Volume	3
Publication status	Published - 2013
Event	Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States Duration: May 12 2013 → May 16 2013

Conference

Conference	Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Country/Territory	United States
City	Washington, DC
Period	5/12/13 → 5/16/13

Keywords

Bone repair
Chitosan
F127
In situ forming gel
Viscoelastic properties

ASJC Scopus subject areas

Biotechnology

Cite this

Vu Thai, KT, Yang, MC & Lai, WF 2013, Evaluation of F127/chitosan hydrogel as a scaffold for bone repair. in Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. vol. 3, pp. 187-190, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013, Washington, DC, United States, 5/12/13.

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title = "Evaluation of F127/chitosan hydrogel as a scaffold for bone repair",

abstract = "An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (Tgel), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature due to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.",

keywords = "Bone repair, Chitosan, F127, In situ forming gel, Viscoelastic properties",

author = "{Vu Thai}, {K. T.} and Yang, {M. C.} and Lai, {W. F.}",

year = "2013",

language = "English",

isbn = "9781482205862",

volume = "3",

pages = "187--190",

booktitle = "Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013",

note = "Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 ; Conference date: 12-05-2013 Through 16-05-2013",

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TY - GEN

T1 - Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

AU - Vu Thai, K. T.

AU - Yang, M. C.

AU - Lai, W. F.

PY - 2013

Y1 - 2013

N2 - An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (Tgel), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature due to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.

AB - An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (Tgel), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature due to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.

KW - Bone repair

KW - Chitosan

KW - F127

KW - In situ forming gel

KW - Viscoelastic properties

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UR - http://www.scopus.com/inward/citedby.url?scp=84881086115&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84881086115

SN - 9781482205862

VL - 3

SP - 187

EP - 190

BT - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

T2 - Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

Y2 - 12 May 2013 through 16 May 2013

ER -

Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

Abstract

Conference

Keywords

ASJC Scopus subject areas

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