Abstract
Purpose: This study was to evaluate the feasibility of dose conformity and tumor control probability calculated for CyberKnife(superscript ®) hypofractionated planning for prostate cancer.
Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript ®). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.
Results: The CI and nCI of the CyberKnife(superscript ®) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3%. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.
Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.
Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript ®). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.
Results: The CI and nCI of the CyberKnife(superscript ®) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3%. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.
Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.
| Translated title of the contribution | 以劑量包覆順型度數學模型和腫瘤控制機率模式評估攝護腺癌在放射手術電腦刀治療計畫系統 |
|---|---|
| Original language | English |
| Pages (from-to) | 301-310 |
| Number of pages | 10 |
| Journal | 放射治療與腫瘤學 |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2008 |
Keywords
- Conformity index
- Tumor control probability
- Stereotactic radiosurgery
- CyberKnife
