Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Ching Yu Yen; Chien Yang Huang; Ming Feng Hou; Yi Hsin Yang; Chao Hsiang Chang; Hurng Wern Huang; Chung Ho Chen; Hsueh Wei Chang

doi:10.3109/1354750X.2012.737025

Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Ching Yu Yen
, Chien Yang Huang
, Ming Feng Hou
, Yi Hsin Yang
, Chao Hsiang Chang
, Hurng Wern Huang
, Chung Ho Chen
, Hsueh Wei Chang

School of Dentistry

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Biomarkers
Volume	18
Issue number	1
DOIs	https://doi.org/10.3109/1354750X.2012.737025
Publication status	Published - Feb 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Extracellular matrix
Fibronectin 1
Glycoprotein CD44
Integrin α4β1
Oral squamous cell carcinoma
Receiver-operating characteristic curves
Syndecan-2
Tumor marker

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2012.737025

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Yen, C. Y., Huang, C. Y., Hou, M. F., Yang, Y. H., Chang, C. H., Huang, H. W., Chen, C. H., & Chang, H. W. (2013). Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC). Biomarkers, 18(1), 63-72. https://doi.org/10.3109/1354750X.2012.737025

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abstract = "Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80\%/84\% and 88\%/52\%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.",

keywords = "Extracellular matrix, Fibronectin 1, Glycoprotein CD44, Integrin α4β1, Oral squamous cell carcinoma, Receiver-operating characteristic curves, Syndecan-2, Tumor marker",

author = "Yen, \{Ching Yu\} and Huang, \{Chien Yang\} and Hou, \{Ming Feng\} and Yang, \{Yi Hsin\} and Chang, \{Chao Hsiang\} and Huang, \{Hurng Wern\} and Chen, \{Chung Ho\} and Chang, \{Hsueh Wei\}",

note = "Funding Information: This work was partly supported by the National Science Council in Taiwan (under grant NSC97-2311-B-037-003-MY3), by the ChiMei-KMU joint fund (100CM-KMU-07), by the Department of Health (DOH101-TD-C-111-002), by the Kaohsiung Medical University Research Foundation (KMUER001 and KMU-M110001) and NSYSU-KMU Joint Research Project (\#NSYSUKMU 101-006).",

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doi = "10.3109/1354750X.2012.737025",

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AU - Yen, Ching Yu

AU - Huang, Chien Yang

AU - Hou, Ming Feng

AU - Yang, Yi Hsin

AU - Chang, Chao Hsiang

AU - Huang, Hurng Wern

AU - Chen, Chung Ho

AU - Chang, Hsueh Wei

N1 - Funding Information: This work was partly supported by the National Science Council in Taiwan (under grant NSC97-2311-B-037-003-MY3), by the ChiMei-KMU joint fund (100CM-KMU-07), by the Department of Health (DOH101-TD-C-111-002), by the Kaohsiung Medical University Research Foundation (KMUER001 and KMU-M110001) and NSYSU-KMU Joint Research Project (#NSYSUKMU 101-006).

PY - 2013/2

Y1 - 2013/2

N2 - Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.

AB - Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.

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KW - Integrin α4β1

KW - Oral squamous cell carcinoma

KW - Receiver-operating characteristic curves

KW - Syndecan-2

KW - Tumor marker

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Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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