Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Ching Yu Yen; Chien Yang Huang; Ming Feng Hou; Yi Hsin Yang; Chao Hsiang Chang; Hurng Wern Huang; Chung Ho Chen; Hsueh Wei Chang

doi:10.3109/1354750X.2012.737025

Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Ching Yu Yen, Chien Yang Huang, Ming Feng Hou, Yi Hsin Yang, Chao Hsiang Chang, Hurng Wern Huang, Chung Ho Chen, Hsueh Wei Chang

School of Dentistry

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Biomarkers
Volume	18
Issue number	1
DOIs	https://doi.org/10.3109/1354750X.2012.737025
Publication status	Published - Feb 2013

Keywords

Extracellular matrix
Fibronectin 1
Glycoprotein CD44
Integrin α4β1
Oral squamous cell carcinoma
Receiver-operating characteristic curves
Syndecan-2
Tumor marker

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2012.737025

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Yen, C. Y., Huang, C. Y., Hou, M. F., Yang, Y. H., Chang, C. H., Huang, H. W., Chen, C. H., & Chang, H. W. (2013). Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC). Biomarkers, 18(1), 63-72. https://doi.org/10.3109/1354750X.2012.737025

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abstract = "Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.",

keywords = "Extracellular matrix, Fibronectin 1, Glycoprotein CD44, Integrin α4β1, Oral squamous cell carcinoma, Receiver-operating characteristic curves, Syndecan-2, Tumor marker",

author = "Yen, {Ching Yu} and Huang, {Chien Yang} and Hou, {Ming Feng} and Yang, {Yi Hsin} and Chang, {Chao Hsiang} and Huang, {Hurng Wern} and Chen, {Chung Ho} and Chang, {Hsueh Wei}",

note = "Funding Information: This work was partly supported by the National Science Council in Taiwan (under grant NSC97-2311-B-037-003-MY3), by the ChiMei-KMU joint fund (100CM-KMU-07), by the Department of Health (DOH101-TD-C-111-002), by the Kaohsiung Medical University Research Foundation (KMUER001 and KMU-M110001) and NSYSU-KMU Joint Research Project (#NSYSUKMU 101-006).",

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doi = "10.3109/1354750X.2012.737025",

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AU - Yen, Ching Yu

AU - Huang, Chien Yang

AU - Hou, Ming Feng

AU - Yang, Yi Hsin

AU - Chang, Chao Hsiang

AU - Huang, Hurng Wern

AU - Chen, Chung Ho

AU - Chang, Hsueh Wei

N1 - Funding Information: This work was partly supported by the National Science Council in Taiwan (under grant NSC97-2311-B-037-003-MY3), by the ChiMei-KMU joint fund (100CM-KMU-07), by the Department of Health (DOH101-TD-C-111-002), by the Kaohsiung Medical University Research Foundation (KMUER001 and KMU-M110001) and NSYSU-KMU Joint Research Project (#NSYSUKMU 101-006).

PY - 2013/2

Y1 - 2013/2

N2 - Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.

AB - Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.

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KW - Receiver-operating characteristic curves

KW - Syndecan-2

KW - Tumor marker

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Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Abstract

Keywords

ASJC Scopus subject areas

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