Evaluating the feasibility of applying cobalt-hydroxyapatite ingots as radiotherapy markers

Wei Chun Lin, Cheng Ming Tang, Cheng Chang Lu, Chun Chao Chuang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The substitution of cobalt for calcium in hydroxyapatite produces CoHA with a higher effective atomic number. This study evaluates various medical imaging characteristics of round CoHA ingots in a porcine phantom to demonstrate the feasibility of using CoHA ingots as radiotherapy markers. CoHA was compressed into round ingots and then implanted into a porcine liver phantom and a gelatin porcine vertebra phantom along with three commercially available radiotherapy markers. The phantom was respectively scanned and photographed using a routine x-ray imager, magnetic resonance imager, computed tomography (CT) imager, and ultrasound imager followed by image analysis in ImageJ software. CoHA ingots could be clearly identified with general imaging instruments (x-ray, CT, and ultrasound) and the image size did not change. There were some metal artifacts in the magnetic resonance images. Biodegradable CoHA ingots can be self-absorbed by the body over time to avoid interference with follow-up disease screening and can be used with most medical imaging instruments quickly to help identify the location and extent of soft-tissue tumors.

Original languageEnglish
Article number101162
JournalMaterials Today Communications
Publication statusPublished - Sept 2020


  • CoHA ingots
  • Fiducials
  • Hydroxyapatite
  • Image-guided
  • Radiotherapy (RT)

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Materials Chemistry


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