Evaluating The Effects of Traditional Herbal Medicine X-911 on Cytokine Expression and Glucose Uptake in LL2 Cells With 18F-FDG/MicroPET

Shiou Shiow Farn, Yu-An Chen, Kang-Wei Chang

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Traditional Chinese medicine (TCM) is empirically based, used to activate circulation alone or in combination with anticancer drugs. X-911, a kind of TCM extracted from plant sterols, optimal functioning of the immune system. To study the independent or combined use of X-911 in the treatment of allograft animal model on assessment of the effects of this treatment on tumor growth and cytokine expression was performed. After LL2 implantation, we administered X-911 (0.25 g or 0.125 g) for two weeks. Tumor growth, microPET imaging (18F-FDG) and cytokine assay were measured. Tumor glycolysis was obtained from 18F-FDG microPET imaging, and cytokine assay between T cell helper 1 (Th1) and Th2 cells will perform analysis by multiplex cytokine assay. Accumulated inhibition of tumor growth by X-911 and changed the balance between T cell helper 1 (Th1) and Th2 cells by increasing Th1 cytokine expression, thus inhibiting tumor growth. Identified the functional image and biological mechanism of action of a TCM and demonstrate its curative effects on the body.
Original languageChinese (Traditional)
JournalAmerican Journal of Biomedical Science and Research
Issue number1
Publication statusPublished - Aug 2021

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