Estrogen, estrogen receptor and lung cancer

Li Han Hsu, Nei Min Chu, Shu Huei Kao

Research output: Contribution to journalReview articlepeer-review

145 Citations (Scopus)


Estrogen has been postulated as a contributor for lung cancer development and progression. We reviewed the current knowledge about the expression and prognostic implications of the estrogen receptors (ER) in lung cancer, the effect and signaling pathway of estrogen on lung cancer, the hormone replacement therapy and lung cancer risk and survival, the mechanistic relationship between the ER and the epidermal growth factor receptor (EGFR), and the relevant clinical trials combining the ER antagonist and the EGFR antagonist, to investigate the role of estrogen in lung cancer. Estrogen and its receptor have the potential to become a prognosticator and a therapeutic target in lung cancer. On the other hand, tobacco smoking aggravates the effect of estrogen and endocrine disruptive chemicals from the environment targeting ER may well contribute to the lung carcinogenesis. They have gradually become important issues in the course of preventive medicine.

Original languageEnglish
Article number1713
JournalInternational Journal of Molecular Sciences
Issue number8
Publication statusPublished - Aug 5 2017


  • Epidermal growth factor receptor
  • Estrogen
  • Estrogen receptor
  • Hormone
  • Lung adenocarcinoma
  • Lung cancer

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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