Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats

Akira Ohtsu; Noriyuki Saitoh; Nobuo Okada; Wen Chang Chang; Seiitsu Murota

doi:10.1016/0049-3848(83)90058-0

Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats

Akira Ohtsu, Noriyuki Saitoh, Nobuo Okada, Wen Chang Chang, Seiitsu Murota

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.

Original language	English
Pages (from-to)	567-574
Number of pages	8
Journal	Thrombosis Research
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/0049-3848(83)90058-0
Publication status	Published - Dec 15 1983
Externally published	Yes

Keywords

Aorta
Estradiol
Prostacyclin Production
Thrombosis

ASJC Scopus subject areas

Hematology

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10.1016/0049-3848(83)90058-0

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title = "Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats",

abstract = "The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.",

keywords = "Aorta, Estradiol, Prostacyclin Production, Thrombosis",

author = "Akira Ohtsu and Noriyuki Saitoh and Nobuo Okada and Chang, {Wen Chang} and Seiitsu Murota",

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T1 - Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats

AU - Ohtsu, Akira

AU - Saitoh, Noriyuki

AU - Okada, Nobuo

AU - Chang, Wen Chang

AU - Murota, Seiitsu

PY - 1983/12/15

Y1 - 1983/12/15

N2 - The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.

AB - The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.

KW - Aorta

KW - Estradiol

KW - Prostacyclin Production

KW - Thrombosis

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JF - Thrombosis Research

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ER -

Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats

Abstract

Keywords

ASJC Scopus subject areas

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