Epstein-Barr virus and lymphoid hematological disorders

An Tie Hsieh, Ching Liang Ho, Yeu Chin Chen, Wei Yau Kao, Tsu Yi Chao

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background. To study the role of Epstein-Barr virus (EBV) in the carcinogenesis of various lymphoid neoplasms in Taiwan, a nonisotopic in situ hybridization (ISH) technique was used to detect the expression of EBV-encoded small RNAs (EBERs) in various lymphoid neoplasms. Methods. We obtained the paraffin-embedded tissues of various hematological malignancies from the department of Pathology, Tri-Service General Hospital. Nonisotopic ISH technique was employed to detect EBERs and immunohistochemical staining was performed to confirm the cell lineage. Results. Our data showed the frequency of EBV infection on various lymphoid malignancies as followed: Burkitt's lymphoma (BL) (10/18); non-Burkitt's Non-Hodgkin's lymphoma (3/42); non-Hodgkin's lymphoma, T cell type, nasal (NHLTN) (5/5); Hodgkin's disease (2/9); acute lymphocytic leukemia (1/24); chronic lymphocytic leukemia (1/15); and multiple myeloma (2/18). In the control group, none of the specimens from patients of acute myelocytic leukemia and myelodysplastic syndrome was positive for EBERs. Conclusions. Among the various lymphoid neoplasms we studied, only BL (p<0.05) and NHLTN (p<0.05) were found to have an association with EBV statistically.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalChinese Medical Journal (Taipei)
Issue number3
Publication statusPublished - 2002
Externally publishedYes


  • EBV-encoded small RNAs
  • Epstein-Barr virus
  • In situ hybridization
  • Lymphoid neoplasm

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Epstein-Barr virus and lymphoid hematological disorders'. Together they form a unique fingerprint.

Cite this