TY - JOUR
T1 - Epitranscriptome and fmrp regulated mrna translation
AU - Majumder, Pritha
AU - Chatterjee, Biswanath
AU - James Shen, C. K.
N1 - Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
PY - 2017/9
Y1 - 2017/9
N2 - An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).
AB - An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).
KW - Dendritic local translation
KW - Epitranscriptome
KW - FMRP
KW - Neurological diseases
KW - RNA editing
KW - RNA methylation
KW - TDP-43
UR - http://www.scopus.com/inward/record.url?scp=85075672862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075672862&partnerID=8YFLogxK
U2 - 10.3390/epigenomes1020011
DO - 10.3390/epigenomes1020011
M3 - Review article
AN - SCOPUS:85075672862
SN - 2075-4655
VL - 1
JO - Epigenomes
JF - Epigenomes
IS - 2
M1 - 11
ER -