Epitranscriptome and fmrp regulated mrna translation

Pritha Majumder; Biswanath Chatterjee; C. K. James Shen

doi:10.3390/epigenomes1020011

Epitranscriptome and fmrp regulated mrna translation

Pritha Majumder, Biswanath Chatterjee, C. K. James Shen

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).

Original language	English
Article number	11
Journal	Epigenomes
Volume	1
Issue number	2
DOIs	https://doi.org/10.3390/epigenomes1020011
Publication status	Published - Sept 2017
Externally published	Yes

Keywords

Dendritic local translation
Epitranscriptome
FMRP
Neurological diseases
RNA editing
RNA methylation
TDP-43

ASJC Scopus subject areas

Biochemistry
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Genetics
Health, Toxicology and Mutagenesis

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10.3390/epigenomes1020011

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abstract = "An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).",

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AU - Chatterjee, Biswanath

AU - James Shen, C. K.

N1 - Publisher Copyright: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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N2 - An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).

AB - An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).

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KW - Epitranscriptome

KW - FMRP

KW - Neurological diseases

KW - RNA editing

KW - RNA methylation

KW - TDP-43

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Epitranscriptome and fmrp regulated mrna translation

Abstract

Keywords

ASJC Scopus subject areas

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