Eph and ephrin signaling: Lessons learned from spinal motor neurons

Tzu Jen Kao, Chris Law, Artur Kania

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)


In nervous system assembly, Eph/ephrin signaling mediates many axon guidance events that shape the formation of precise neuronal connections. However, due to the complexity of interactions between Ephs and ephrins, the molecular logic of their action is still being unraveled. Considerable advances have been made by studying the innervation of the limb by spinal motor neurons, a series of events governed by Eph/ephrin signaling. Here, we discuss the contributions of different Eph/ephrin modes of interaction, downstream signaling and electrical activity, and how these systems may interact both with each other and with other guidance molecules in limb muscle innervation. This simple model system has emerged as a very powerful tool to study this set of molecules, and will continue to be so by virtue of its simplicity, accessibility and the wealth of pioneering cellular studies.

Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalSeminars in Cell and Developmental Biology
Issue number1
Publication statusPublished - Feb 2012
Externally publishedYes


  • Axon guidance
  • Eph
  • Ephrin
  • Motor neuron

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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