TY - JOUR
T1 - Enhancing the blood response and antibacterial adhesion of titanium surface through oxygen plasma immersion ion implantation treatment
AU - Shiau, Duen Kai
AU - Yang, Chih Hsiung
AU - Sun, Ying Sui
AU - Wu, Mei Fang
AU - Pan, Haobo
AU - Huang, Her Hsiung
N1 - Funding Information:
The authors would thank the partially financial support and assistance in O-PIII treatment from Institute of Nuclear Energy Research, Atomic Energy Council (No. 1002001INER036), Taiwan. Thanks are also due to the partial support from Shenzhen Peacock Program (No. 110811003586331), China.
Funding Information:
The authors would thank the partially financial support and assistance in O-PIII treatment from Institute of Nuclear Energy Research, Atomic Energy Council (No. 1002001INER036 ), Taiwan. Thanks are also due to the partial support from Shenzhen Peacock Program (No. 110811003586331 ), China.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/5/15
Y1 - 2019/5/15
N2 - Titanium (Ti) is a biocompatible alloy widely used in dental implants, thanks to the protective Ti oxide film that forms spontaneously on the surface. Unfortunately, the film is bioinert and prone to the release of metal ions. In a previous study, we applied oxygen plasma immersion ion implantation (O-PIII) treatment to Ti surface to enhance the corrosion resistance and cell response of Ti. In this study, we examined the surface characteristics of the treated alloy, including roughness, hydrophilicity, and chemical composition. We investigated the blood response to the O-PIII-treated Ti surfaces, including the blood-clotting ability and platelet adhesion. We also investigated resistance of the treated alloy to the adhesion of oral bacteria, Streptococcus mutans, in terms of bacterial attachment and morphology. Our results demonstrate that O-PIII treatment did not have a significant effect on surface roughness or hydrophilicity. This treatment resulted in the formation of a Ti oxide film containing mainly TiO 2 , Ti 2 O 3 , and TiO. The presence of surface Ti oxides (particularly TiO 2 ) positively influenced blood-clotting ability and platelet adhesion as well as resistance to bacterial adhesion. These effects were particularly evident when O-PIII treatment was applied at a higher voltage. Our results demonstrate that the proposed O-PIII treatment promotes blood-clotting and resistance to bacterial adhesion in dental implant applications.
AB - Titanium (Ti) is a biocompatible alloy widely used in dental implants, thanks to the protective Ti oxide film that forms spontaneously on the surface. Unfortunately, the film is bioinert and prone to the release of metal ions. In a previous study, we applied oxygen plasma immersion ion implantation (O-PIII) treatment to Ti surface to enhance the corrosion resistance and cell response of Ti. In this study, we examined the surface characteristics of the treated alloy, including roughness, hydrophilicity, and chemical composition. We investigated the blood response to the O-PIII-treated Ti surfaces, including the blood-clotting ability and platelet adhesion. We also investigated resistance of the treated alloy to the adhesion of oral bacteria, Streptococcus mutans, in terms of bacterial attachment and morphology. Our results demonstrate that O-PIII treatment did not have a significant effect on surface roughness or hydrophilicity. This treatment resulted in the formation of a Ti oxide film containing mainly TiO 2 , Ti 2 O 3 , and TiO. The presence of surface Ti oxides (particularly TiO 2 ) positively influenced blood-clotting ability and platelet adhesion as well as resistance to bacterial adhesion. These effects were particularly evident when O-PIII treatment was applied at a higher voltage. Our results demonstrate that the proposed O-PIII treatment promotes blood-clotting and resistance to bacterial adhesion in dental implant applications.
KW - Antibacterial adhesion
KW - Blood response
KW - Dental implant surface
KW - Oxygen plasma immersion ion implantation
KW - Titanium
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U2 - 10.1016/j.surfcoat.2018.05.029
DO - 10.1016/j.surfcoat.2018.05.029
M3 - Article
AN - SCOPUS:85048714160
SN - 0257-8972
VL - 365
SP - 173
EP - 178
JO - Surface and Coatings Technology
JF - Surface and Coatings Technology
ER -