Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

Vijendra K. Singh; Sy Jye Christine Leu

doi:10.1016/0304-3940(90)90025-5

Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

Vijendra K. Singh, Sy Jye Christine Leu

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

Original language	English
Pages (from-to)	151-154
Number of pages	4
Journal	Neuroscience Letters
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(90)90025-5
Publication status	Published - Dec 11 1990
Externally published	Yes

Keywords

Corticotropin-releasing factor
Interleukin production
Neuroimmunomodulation

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(90)90025-5

Cite this

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abstract = "Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.",

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AU - Leu, Sy Jye Christine

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Y1 - 1990/12/11

N2 - Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

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KW - Interleukin production

KW - Neuroimmunomodulation

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Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

Abstract

Keywords

ASJC Scopus subject areas

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