Enhanced Risk of Osteoporotic Fracture in Patients with Sarcopenia: A National Population‐Based Study in Taiwan

Han Wei Zhang, Zhi Ren Tsai, Ko Ta Chen, Sheng Lun Hsu, Yi Jie Kuo, Ying Chin Lin, Shu Wei Huang, Yu Pin Chen, Hsiao Ching Peng, Jeffrey J.P. Tsai, Chun Yi Hsu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Sarcopenia is a progressive and generalized skeletal muscle disorder associated with poor health outcomes in older adults. However, its association with the risk of fracture risk is yet to be clarified. Therefore, this study aimed to assess the incidence and consequence of osteoporosis‐re-lated fractures among patients with sarcopenia in Taiwan. A retrospective, population‐based study on 616 patients with sarcopenia, aged >40 years, and 1232 individuals without sarcopenia was conducted to evaluate claims data from Taiwan’s National Health Insurance Research Database col-lected in the period January 2000–December 2013. The incidence rate of osteoporosis‐related fracture was 18.13 and 14.61 per 1000 person years in the patients with sarcopenia and comparison cohort, respectively. Patients with sarcopenia had a greater osteoporotic fracture risk (adjusted haz-ard ratio [HR] 2.11; 95% confidence interval [CI] 1.47–3.04) after correcting for possible confound-ing. Additionally, females showed statistically significant correlations of sarcopenia with osteopo-rosis‐related fracture risk (HR 1.53; CI 0.83–2.8 for males and HR 2.40, CI 1.51–3.81 for females). During this retrospective study on the fracture risk in Taiwan, an adverse impact of sarcopenia was observed, which substantiates the need to work toward sarcopenia prevention and interventions to reverse fracture susceptibility in patients with sarcopenia.

Original languageEnglish
Article number791
JournalJournal of Personalized Medicine
Issue number5
Publication statusPublished - May 2022


  • fracture
  • incidence
  • nationwide population‐based study
  • osteoporosis
  • sarcopenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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