Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain

Cheng Hsun Wu; Yi Ping Chen; Si Han Wu; Yann Hung; Chung Yuan Mou; Richard P. Cheng

doi:10.1021/am4039882

Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain

Cheng Hsun Wu, Yi Ping Chen, Si Han Wu, Yann Hung, Chung Yuan Mou, Richard P. Cheng

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.

Original language	English
Pages (from-to)	12244-12248
Number of pages	5
Journal	ACS Applied Materials and Interfaces
Volume	5
Issue number	23
DOIs	https://doi.org/10.1021/am4039882
Publication status	Published - Dec 11 2013
Externally published	Yes

Keywords

arginine analogs
cellular uptake
mesoporous materials
non-natural peptides
nonendocytosis

ASJC Scopus subject areas

General Materials Science

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10.1021/am4039882

Cite this

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abstract = "Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.",

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AU - Wu, Cheng Hsun

AU - Chen, Yi Ping

AU - Wu, Si Han

AU - Hung, Yann

AU - Mou, Chung Yuan

AU - Cheng, Richard P.

PY - 2013/12/11

Y1 - 2013/12/11

N2 - Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.

AB - Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.

KW - arginine analogs

KW - cellular uptake

KW - mesoporous materials

KW - non-natural peptides

KW - nonendocytosis

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Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain

Abstract

Keywords

ASJC Scopus subject areas

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