Abstract
The pharmacological action of higenamine in isolated rat aorta was investigated. Although the beta-adrenoceptor antagonist propranolol (1 x 10-5 M) completely blocked the beta-adrenoceptor agonist higenamine in inducing a positive chronotropic activity in isolated mouse atria, the higenamine-induced aortic relaxation was not completely antagonized by this concentration of propranolol. The present data also demonstrate that the higenamine-induced aortic relaxation was attenuated in the absence of endothelium. These findings suggest that the beta-adrenoceptor specificity to higenamine in aorta is different from that of beta-1 in atria; moreover, the beta-adrenoceptors sensitive to higenamine are mainly located in the endothelial layer.
| Original language | English |
|---|---|
| Pages (from-to) | 130-132 |
| Number of pages | 3 |
| Journal | Planta Medica |
| Volume | 63 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1997 |
Keywords
- Aconitum japonicum
- aortic relaxation
- benzylisoquinoline alkaloid
- beta-adrenoceptor
- endothelium
- higenamine
- propranolol
- Ranunculaceae
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry