Endoscopic balloon-based radiofrequency ablation for long-segment early esophageal squamous cell neoplasia

Ying-Nan Tsai, Ching Tai Lee, Tao-Qian Tang, I-Wei Chang, Chi Yang Chang, Lein Ray Mo, Wen Lun Wang

Research output: Contribution to journalArticlepeer-review


Esophageal cancer is a common and highly lethal disease. In the Asia-Pacific region, esophageal squamous cell neoplasias are the major forms of the disease. Recent advances in endoscopic therapy enable curative treatment of early esophageal squamous cell neoplasias, however, the technique is complicated and requires a high level of expertise, especially for those with long-segment lesions. Endoscopic radiofrequency ablation is a rapidly evolving treatment modality and has been shown to have good efficacy and safety for the treatment of dysplasia in cases of Barrett’s esophagus. Theoretically, it can also be used to treat squamous dysplasia. We report a case of a 48-year-old man with an 8-cm-long circumferential squamous high-grade dysplasia over the esophagus (from 21 cm to 29 cm below the incisor) that was treated successfully and safely with balloon-based radiofrequency ablation. The procedure took only around 30 minutes to complete. There were no major adverse events during and after the procedure. In addition, we examined the histology of the esophageal coagulum, which showed an extensive cauterization effect with focal dysplasia within the ablated epithelium. Follow-up endoscopy at 1 month, 3 months, and 6 months showed no residual lesion, and biopsies also confirmed complete remission.
Original languageEnglish
Pages (from-to)187-190
JournalAdvances in Digestive Medicine
Issue number4
Publication statusPublished - 2016
Externally publishedYes


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